Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.02.002
Abstract: Three structurally related tyrosine receptor cell surface kinases, Tyro3, Axl, and Mertk (TAM) have been recognized to modulate immune function, tissue homeostasis, cardiovasculature, and cancer. The TAM receptor family appears to operate in adult mammals… read more here.
Keywords: immune; axl mertk; efferocytosis; tyro3 axl ... See more keywords
Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer"
DOI: 10.1186/s12943-019-1022-2
Abstract: Tumor-associated macrophages are an abundant cell type in the tumor microenvironment. These macrophages serve as a promising target for treatment of cancer due to their roles in promoting cancer progression and simultaneous immunosuppression. The TAM… read more here.
Keywords: tam receptors; tyro3 axl; cancer; tumor microenvironment ... See more keywords