Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology
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DOI: 10.1007/s00401-017-1737-3
Abstract: Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer’s disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2,… read more here.
Keywords: protein; psen1; tyrobp; pathology ... See more keywords
Higher TYROBP and lower SOX6 as predictive biomarkers for poor prognosis of clear cell renal cell carcinoma: A pilot study
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DOI: 10.1097/md.0000000000030658
Abstract: Background: Clear cell renal carcinoma (ccRCC) is the most common subtype of renal cancer, accounting for approximately 75% of all histological types of renal cancer, and is the leading cause of death from renal cancer.… read more here.
Keywords: tyrobp; cell; expression; clear cell ... See more keywords
The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy
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DOI: 10.7150/ijms.66929
Abstract: Human fibroleukin 2 (Fgl2), a member of the fibrinogen superfamily, can cleave prothrombin to generate thrombin or is secreted in a soluble form as a new type of effector of Tregs with immunomodulatory functions. However,… read more here.
Keywords: tyrobp; cell; cutaneous squamous; cscc ... See more keywords