Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1737-3
Abstract: Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer’s disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2,… read more here.
Keywords: protein; psen1; tyrobp; pathology ... See more keywords
Higher TYROBP and lower SOX6 as predictive biomarkers for poor prognosis of clear cell renal cell carcinoma: A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030658
Abstract: Background: Clear cell renal carcinoma (ccRCC) is the most common subtype of renal cancer, accounting for approximately 75% of all histological types of renal cancer, and is the leading cause of death from renal cancer.… read more here.
Keywords: tyrobp; cell; expression; clear cell ... See more keywords
Trem2/Tyrobp Signaling Protects Against Aortic Dissection and Rupture by Inhibiting Macrophage Activation in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.124.321429
Abstract: BACKGROUND: The development of aortic dissection (AD) is closely associated with inflammation. The Trem2 (triggering receptor expressed on myeloid cells 2)/Tyrobp (TYRO protein tyrosine kinase-binding protein) signaling pathway critically regulates innate immunity and has emerged… read more here.
Keywords: mice; tyrobp; aortic dissection; trem2 ... See more keywords
Drug screening targeting TREM2-TYROBP transmembrane binding
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DOI: 10.1186/s10020-025-01229-y
Abstract: TREM2 encodes a microglial membrane receptor involved in the disease-associated microglia (DAM) phenotype whose activation requires the transmembrane interaction with TYROBP. Mutations in TREM2 represent a high-impact risk factor for Alzheimer’s disease (AD) which turned… read more here.
Keywords: drug screening; trem2 tyrobp; tyrobp; tyrobp transmembrane ... See more keywords
Low TYROBP expression predicts poor prognosis in multiple myeloma
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DOI: 10.1186/s12935-024-03304-6
Abstract: Multiple myeloma (MM) is the second most common refractory hematologic cancer. Searching for new targets and prognostic markers for MM is significant. GSE39754, GSE6477 and GSE24080 were downloaded from the Gene Expression Omnibus (GEO) database.… read more here.
Keywords: tyrobp expression; tyrobp; cell adhesion; prognosis ... See more keywords
The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.66929
Abstract: Human fibroleukin 2 (Fgl2), a member of the fibrinogen superfamily, can cleave prothrombin to generate thrombin or is secreted in a soluble form as a new type of effector of Tregs with immunomodulatory functions. However,… read more here.
Keywords: tyrobp; cell; cutaneous squamous; cscc ... See more keywords