1,2,3‐Triazole‐linked 5‐benzylidene (thio)barbiturates as novel tyrosinase inhibitors and free‐radical scavengers
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000058
Abstract: In this study, benzyl‐1,2,3‐triazole‐linked 5‐benzylidene (thio)barbiturate derivatives 7a–d and 8a–h were designed as potential tyrosinase inhibitors and free‐radical scavengers. The twelve derivatives were synthesized via the [3+2] cycloaddition reaction of the corresponding benzyl azide as… read more here.
Keywords: linked benzylidene; triazole linked; tyrosinase inhibitors; free radical ... See more keywords
4‐Fluorobenzylpiperazine‐Containing Derivatives as Efficient Inhibitors of Mushroom Tyrosinase
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DOI: 10.1002/cmdc.202000125
Abstract: Tyrosinase is a type‐3 copper protein involved in the biosynthesis of melanin pigments; therefore, the inhibition of its enzymatic activity represents a promising strategy for the treatment of hyperpigmentation‐related disorders. To address this point, we… read more here.
Keywords: derivatives efficient; containing derivatives; fluorobenzylpiperazine containing; tyrosinase ... See more keywords
In Silico Interactions of the Components from the Schinus terebinthifolius Extract with Human Tyrosinase.
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DOI: 10.1002/cplu.202200109
Abstract: The anti-tyrosinase activity of the leaf extract of Schinus terebinthifolius, also known as Brazilian peppertree, was evaluated using multiple in silico approaches, such as molecular homology, molecular docking, MM-GBSA, molecular dynamics, MM-PBSA, QSAR, and skin permeability… read more here.
Keywords: silico interactions; components schinus; tyrosinase; interactions components ... See more keywords
Tyrosinase covalently immobilized on carboxyl functionalized magnetic nanoparticles for fishing of the enzyme's ligands from Prunellae Spica.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200303
Abstract: In this study, tyrosinase was immobilized on carboxyl functionalized silica-coated magnetic nanoparticles for the first time to be used for fishing of tyrosinase's ligands present in complex plant extract. The immobilized tyrosinase was characterized by… read more here.
Keywords: carboxyl functionalized; microscopy; tyrosinase; magnetic nanoparticles ... See more keywords
Covalent immobilization of tyrosinase on magnetic multi-walled carbon nanotubes for inhibitor screening.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202300195
Abstract: The inhibition of tyrosinase is considered to be a common therapeutic strategy for some hyperpigmentation disorders. Screening of tyrosinase inhibitors is of great significance to the treatment of pigmentation diseases. In this study, tyrosinase was… read more here.
Keywords: carbon nanotubes; tyrosinase; multi walled; magnetic multi ... See more keywords
Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosinase pathway
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23069
Abstract: Skin pigmentation is resulted from several processes, such as melanin synthesis transportation and abnormal melanin accumulation in keratinocytes. Various studies have suggested that seven traditional Chinese herbal extracts from Atractylodes macrocephala, Paeonia lactiflora, Bletilla striata,… read more here.
Keywords: lactobacillus rhamnosus; creb mitf; tyrosinase; pigmentation ... See more keywords
Flow injection tyrosinase biosensor for direct determination of acetaminophen in human urine
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DOI: 10.1007/s00216-019-01687-4
Abstract: AbstractAn amperometric biosensor compatible with a flow injection analysis (FIA) for highly selective determination of acetaminophen (APAP) in a sample of human urine was developed. This biosensor is also suitable for use in the routine… read more here.
Keywords: determination acetaminophen; human urine; biosensor; determination ... See more keywords
Novel 1,2,4-triazole analogues as mushroom tyrosinase inhibitors: synthesis, kinetic mechanism, cytotoxicity and computational studies
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DOI: 10.1007/s11030-020-10102-5
Abstract: We have created a novel series of mushroom tyrosinase inhibitors with 1,2,4-triazole as fundamental skeleton. The target compound 1,2,4-triazol-3-ylthio)- N -phenyl acetamide derivatives 9(a–l) were synthesized by the reaction of 4- and 5-substituted 1,2,4-triazole-3-thiol derivatives… read more here.
Keywords: tyrosinase inhibitors; tyrosinase; mushroom tyrosinase; cytotoxicity ... See more keywords
Bioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials
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DOI: 10.1007/s13205-020-02636-0
Abstract: Novel derivatives were synthesized using natural scaffold, like phenylpropanoids C 6 –C 3 backbone to reduce unfavorable browning of food due to tyrosinase and oxidative spoilage. Most of the compounds displayed mushroom tyrosinase inhibition better… read more here.
Keywords: bioevaluation molecular; docking analysis; anti; tyrosinase ... See more keywords
Enzyme-mediated stiffening hydrogels for probing activation of pancreatic stellate cells.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2016.10.027
Abstract: The complex network of biochemical and biophysical cues in the pancreatic desmoplasia not only presents challenges to the fundamental understanding of tumor progression, but also hinders the development of therapeutic strategies against pancreatic cancer. Residing… read more here.
Keywords: hydrogel; pancreatic stellate; matrix; tyrosinase ... See more keywords
Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.036
Abstract: The present research was designed for the selective synthesis of novel bi-heterocyclic acetamides, 9a-n, and their tyrosinase inhibition to overwhelm the problem of melanogenesis. The structures of newly synthesized compounds were confirmed by spectral techniques… read more here.
Keywords: heterocyclic acetamides; inhibition; novel heterocyclic; tyrosinase ... See more keywords