Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells
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DOI: 10.1002/cbic.202200414
Abstract: Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in… read more here.
Keywords: tyrosine; tyrosination; reveals protein; chemical proteomics ... See more keywords
Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design
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DOI: 10.1371/journal.pcbi.1010236
Abstract: Microtubules and their post-translational modifications are involved in major cellular processes. In severe diseases such as neurodegenerative disorders, tyrosinated tubulin and tyrosinated microtubules are in lower concentration. We present here a mechanistic mathematical model of… read more here.
Keywords: cycle; tyrosination cycle; tyrosination; model ... See more keywords
The role of α-tubulin tyrosination in controlling the structure and function of hippocampal neurons
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DOI: 10.3389/fnmol.2022.931859
Abstract: Microtubules (MTs) are central components of the neuronal cytoskeleton and play a critical role in CNS integrity, function, and plasticity. Neuronal MTs are diverse due to extensive post-translational modifications (PTMs), particularly detyrosination/tyrosination, in which the… read more here.
Keywords: function; role; plasticity; tyrosination ... See more keywords