Photosensitized Oxidative Dimerization at Tyrosine by a Water‐Soluble 4‐Amino‐1,8‐naphthalimide
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100193
Abstract: The oxidation of proteins generates reactive amino acid (AA) residue intermediates, leading to protein modification and cross‐linking. Aerobic studies with peptides and photosensitizers allow for the controlled generation of reactive oxygen species (ROS) and reactive… read more here.
Keywords: amino naphthalimide; amino; oxidation; tyrosine ... See more keywords
Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200414
Abstract: Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in… read more here.
Keywords: tyrosine; tyrosination; reveals protein; chemical proteomics ... See more keywords
Proper cytoskeleton α‐tubulin distribution is concomitant to tyrosine phosphorylation during in vitro capacitation and acrosomal reaction in human spermatozoa
Sign Up to like & getrecommendations! Published in 2020 at "Cytoskeleton"
DOI: 10.1002/cm.21631
Abstract: Spermatozoa motility is a key parameter during the fertilization process. In this context, spermatozoa tyrosine protein phosphorylation and an appropriate cytoskeleton α‐tubulin distribution are some of the most important physiological events involved in motility. However,… read more here.
Keywords: spermatozoa; capacitation; tyrosine; tubulin ... See more keywords
Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25768
Abstract: Many prostate cancer (PCa) recurrences are thought to be due to reactivation of disseminated tumor cells (DTCs). We previously found a role of the TAM family of receptor tyrosine kinases TYRO3, AXL, and MERTK in… read more here.
Keywords: pca; tyrosine; prostate cancer; dormancy ... See more keywords
Assessment of serum phenylalanine and tyrosine isomers in patients with ST‐segment elevation vs non‐ST‐segment elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23613
Abstract: Under conditions of oxidative stress, hydroxyl radicals can oxidize phenylalanine (Phe) into various tyrosine (Tyr) isomers (meta‐, ortho‐, and para‐tyrosine; m‐, o‐, and p‐Tyr), depending on the location of the hydroxyl group on the oxidized… read more here.
Keywords: segment elevation; segment; tyrosine; elevation myocardial ... See more keywords
Protein‐redistribution diet in a case of tyrosine hydroxylase enzyme deficiency
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26963
Abstract: Tyrosine hydroxylase deficiency (THD) is a recessive autosomal hereditary disease that blocks the transformation of tyrosine into levodopa, resulting in dystonia and parkinsonism in children (OMIM #605407). Treatment consists of L-dopa, which has variable efficacy.… read more here.
Keywords: protein redistribution; tyrosine; redistribution diet; tyrosine hydroxylase ... See more keywords
Integrated analysis of proteome, phosphotyrosine‐proteome, tyrosine‐kinome, and tyrosine‐phosphatome in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600361
Abstract: Reversible protein‐tyrosine phosphorylation is catalyzed by the antagonistic actions of protein‐tyrosine kinases (PTKs) and phosphatases (PTPs), and represents a major form of cell regulation. Acute myeloid leukemia (AML) is an aggressive hematological malignancy that results… read more here.
Keywords: analysis; myeloid leukemia; tyrosine; integrated analysis ... See more keywords
High-Throughput Analysis of Mammalian Receptor Tyrosine Kinase Activation in Yeast Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6424-6_3
Abstract: Tyrosine phosphorylation is an essential posttranslational modification in intracellular signaling molecules. Since tyrosine phosphorylation occurs in less than 0.1 % of all phosphorylated amino acids in mammalian cells, it is difficult to detect the nascent… read more here.
Keywords: yeast cells; analysis; tyrosine; receptor ... See more keywords
SH2 Domain Histochemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6762-9_31
Abstract: Among posttranslational modifications, the phosphorylation of tyrosine residues is a key modification in cell signaling. Because of its biological importance, characterization of the cellular state of tyrosine phosphorylation is of great interest. Based on the… read more here.
Keywords: tyrosine phosphorylation; sh2 domain; phosphorylation; tyrosine ... See more keywords
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03556-1
Abstract: Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role… read more here.
Keywords: kinase; tyrosine; dyrk2; cancer ... See more keywords
Synthesis of O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) via Ni(II) complex of (S) tyrosine schiff’s base precursor
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-017-5416-6
Abstract: O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step process starting from RS-tyrosine, (S)BPB and Ni(II) chloride hexahydrate. The precursor was [18F]radiofluorinated, followed by hydrolysis with 2 M HCl to… read more here.
Keywords: 18f fpt; tyrosine; 18f fluoropropan; fluoropropan tyrosine ... See more keywords