TLR4 phosphorylation at tyrosine 672 activates the ERK/c-FOS signaling module for LPS-induced cytokine responses in macrophages.
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DOI: 10.1002/eji.202250056
Abstract: Toll-like receptors (TLRs) engage numerous adaptor proteins and signaling molecules, enabling a complex series of post-translational modifications (PTMs) to mount inflammatory responses. TLRs themselves are post-translationally modified following ligand-induced activation, with this being required to… read more here.
Keywords: phosphorylation tyrosine; inflammatory responses; tyrosine 672; tlr4 phosphorylation ... See more keywords