The expression of tyrosine hydroxylase and DARPP‐32 in the house crow (Corvus splendens) brain
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24649
Abstract: Birds of the family Corvidae which includes diverse species such as crows, rooks, ravens, magpies, jays, and jackdaws are known for their amazing abilities at problem‐solving. Since the catecholaminergic system, especially the neurotransmitter dopamine, plays… read more here.
Keywords: corvus splendens; house; darpp; tyrosine hydroxylase ... See more keywords
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24363
Abstract: Adeno‐associated virus (AAV) vector‐mediated delivery of human α‐synuclein (α‐syn) gene in rat substantia nigra (SN) results in increased expression of α‐syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. Therefore, this… read more here.
Keywords: aav; substantia nigra; expression; downregulation ... See more keywords
Protein‐redistribution diet in a case of tyrosine hydroxylase enzyme deficiency
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26963
Abstract: Tyrosine hydroxylase deficiency (THD) is a recessive autosomal hereditary disease that blocks the transformation of tyrosine into levodopa, resulting in dystonia and parkinsonism in children (OMIM #605407). Treatment consists of L-dopa, which has variable efficacy.… read more here.
Keywords: protein redistribution; tyrosine; redistribution diet; tyrosine hydroxylase ... See more keywords
Silencing tyrosine hydroxylase or dopa decarboxylase gene disrupts cuticle tanning during larva-pupa-adult transformation in Henosepilachna vigintioctopunctata.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6948
Abstract: BACKGROUND The 28-spotted potato ladybird, Henosepilachna vigintioctopunctata, is a notorious defoliator of many solanaceous and cucurbitaceous plants. Tyrosine hydroxylase (TH) and dopa decarboxylase (DDC) are responsible for cuticle tanning pathway in insects. RESULTS We identified… read more here.
Keywords: tyrosine hydroxylase; adult; cuticle tanning; dopa decarboxylase ... See more keywords
Stimulation of L‐type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.18-0180
Abstract: Making high‐quality dopamine (DA)‐producing cells for basic biological or small molecule screening studies is critical for the development of novel therapeutics for disorders of the ventral midbrain. Currently, many ventral midbrain assays have low signal‐to‐noise… read more here.
Keywords: type calcium; ventral midbrain; calcium; tyrosine hydroxylase ... See more keywords
Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1256-9
Abstract: Reduced movement frequency or physical activity (bradykinesia) occurs with high prevalence in the elderly. However, loss of striatal tyrosine hydroxylase (TH) in aging humans, non-human primates, or rodents does not reach the ~ 80% loss threshold… read more here.
Keywords: movement; movement frequency; inhibition; tyrosine hydroxylase ... See more keywords
Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine.
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2017.10.019
Abstract: Dopamine synthesis in the ventral tegmental area (VTA) is necessary for the reinforcement of sexual behavior. The objective of this study determined if sexual stimuli initiates reward, and whether reward is attenuated in sexually inactive… read more here.
Keywords: hydroxylase; exposure; dopamine; ventral tegmental ... See more keywords
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.01.003
Abstract: Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is… read more here.
Keywords: immune functions; premature; female mice; mice ... See more keywords
Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.07.028
Abstract: Amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (DAT) function. This phenomenon is called the… read more here.
Keywords: amphetamine; effect; impaired dopamine; dopamine transporter ... See more keywords
Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.156
Abstract: Tyrosine hydroxylase (TH), which catalyzes the conversion of l-tyrosine to l-DOPA, is the rate-limiting enzyme in the biosynthesis of catecholamines. It is well known that both α-synuclein and 14-3-3 protein family members bind to the… read more here.
Keywords: nt5dc2 sirna; pc12d; regulation nt5dc2; tyrosine hydroxylase ... See more keywords
Evaluation of hybrid and pure DFT methods for the binding of novel ligands in the tyrosine hydroxylase enzyme
Sign Up to like & getrecommendations! Published in 2018 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2018.08.009
Abstract: Abstract The M06-2X, M06-L, and M06 functionals were used to evaluate the interaction energies of novel ligands in the TyrOH active site. TyrOH is the rate determining enzyme in the catecholamine-dopamine pathway, converting tyrosine to… read more here.
Keywords: novel ligands; tyrosine hydroxylase; m06 m06; active site ... See more keywords