Hippo Pathway Regulation by Tyrosine Kinases.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_17
Abstract: The Hippo pathway utilizes a well-characterized Ser/Thr kinase cascade to control the downstream effectors, Yap and Taz. In addition, Yap/Taz and other Hippo pathway components are directly regulated by tyrosine kinases (TKs). The methodological strategies… read more here.
Keywords: pathway; pathway regulation; tyrosine kinases; hippo pathway ... See more keywords
Acquired Resistance to Drugs Targeting Tyrosine Kinases
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2018.02.003
Abstract: Abstract Resistance to chemotherapeutic drugs exemplifies the greatest hindrance to effective treatment of cancer patients. The molecular mechanisms responsible have been investigated for over 50 years and have revealed the lack of a single cause,… read more here.
Keywords: targeting tyrosine; tyrosine; acquired resistance; resistance ... See more keywords
ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109834
Abstract: WNTs play key roles in development and disease, signaling through Frizzled (FZD) seven-pass transmembrane receptors and numerous co-receptors including ROR and RYK family receptor tyrosine kinases (RTKs). We describe crystal structures and WNT-binding characteristics of… read more here.
Keywords: structures suggest; ror ryk; receptor tyrosine; tyrosine kinases ... See more keywords
Roles of tyrosine kinases and phosphatases in the formation and dispersal of acetylcholine receptor clusters
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135054
Abstract: The formation of acetylcholine receptor (AChR) clusters at the postsynaptic muscle membrane in response to motor innervation is a key event in the development of the neuromuscular junction. The synaptic AChR clustering process is initiated… read more here.
Keywords: dispersal; formation; tyrosine kinases; achr ... See more keywords
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00685
Abstract: Tyrosine kinases (TKs) play essential roles in signaling processes that regulate cell survival, migration, and proliferation. Dysregulation of tyrosine kinases underlies many disorders, including cancer, cardiovascular and developmental diseases, as well as pathologies of the… read more here.
Keywords: tyrosine kinases; systemic lupus; lupus erythematosus; nonreceptor tyrosine ... See more keywords
Mapping Tyrosine Kinases Based on a TK Activity-Representing Peptide Library Reveals a Role for SRC in H1975 Drug Resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00980
Abstract: Tyrosine kinases (TKs) are prominent targets in cancer therapies, and more than 30 TK inhibitors have been approved for treatments in tumors with abnormal TK. Disappointingly, an incomplete response can occur with the long-term use… read more here.
Keywords: tyrosine kinases; activity; resistance; activity representing ... See more keywords
Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms
Sign Up to like & getrecommendations! Published in 2019 at "Nature medicine"
DOI: 10.1038/s41591-019-0653-6
Abstract: Histiocytoses are clonal hematopoietic disorders frequently driven by mutations mapping to the BRAF and MEK1 and MEK2 kinases. Currently, however, the developmental origins of histiocytoses in patients are not well understood, and clinically meaningful therapeutic… read more here.
Keywords: additional receptor; mutations csf; receptor tyrosine; activating mutations ... See more keywords
Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83069-4
Abstract: Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhibitory potential and… read more here.
Keywords: lung pancreatic; pancreatic cancer; receptor tyrosine; tyrosine kinases ... See more keywords
Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213090120
Abstract: Many types of human cancers are being treated with small molecule ATP-competitive inhibitors targeting the kinase domain of receptor tyrosine kinases. Despite initial successful remission, long-term treatment almost inevitably leads to the emergence of drug… read more here.
Keywords: tyrosine; gatekeeper mutations; tyrosine kinases; receptor tyrosine ... See more keywords
Interactions of quercetin with receptor tyrosine kinases associated with human lung carcinoma
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DOI: 10.1080/14786419.2017.1385015
Abstract: Abstract Lung cancer is a deadly form of cancer with high morbidity and mortality rates. Deregulated receptor tyrosine kinases (RTKs) are frequently associated with the formation and development of lung carcinoma. Quercetin is a major… read more here.
Keywords: receptor tyrosine; human lung; tyrosine kinases; lung cancer ... See more keywords
Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Immunology Research"
DOI: 10.1155/2017/4347121
Abstract: Neutrophils play a critical role in innate immunity and also influence adaptive immune responses. This occurs in good part through their production of inflammatory and immunomodulatory cytokines, in conjunction with their prolonged survival at inflamed… read more here.
Keywords: src family; regulation discrete; discrete functional; tyrosine kinases ... See more keywords