Impact of tyrosine nitration at positions Tyr307 and Tyr335 on structural dynamics of Lipoprotein-associated phospholipase A2-A therapeutically important cardiovascular biomarker for atherosclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.10.068
Abstract: Protein tyrosine nitration (PTN) is a post translational event which results in the generation of 3-Nitrotyrosine (3-NT). High levels of 3-NT were reported in several human diseases such as Parkinson's disease, Alzheimer's disease, amylotrophic lateral… read more here.
Keywords: lipoprotein associated; tyr307 tyr335; tyrosine nitration; associated phospholipase ... See more keywords
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00568
Abstract: Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-controlled reaction of the free radicals superoxide (O2•-) and nitric oxide (•NO). In this review, we first analyze the biochemical evidence for the formation… read more here.
Keywords: biochemistry; reactions peroxynitrite; protein; tyrosine nitration ... See more keywords
Genetically Encoded Protein Tyrosine Nitration in Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00371
Abstract: Tyrosine nitration has served as a major biomarker for oxidative stress and is present in high abundance in over 50 disease pathologies in humans. While data mounts on specific disease pathways from specific sites of… read more here.
Keywords: nitration; tyrosine nitration; protein tyrosine; genetically encoded ... See more keywords
SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin‐deficient mice
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DOI: 10.14814/phy2.14215
Abstract: The sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is the predominant isoform in cardiac muscles and is inhibited by phospholamban (PLN). Under conditions of oxidative… read more here.
Keywords: serca2a tyrosine; serca function; tyrosine nitration; mice ... See more keywords
Protein Tyrosine Nitration in Plant Nitric Oxide Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.859374
Abstract: Nitric oxide (NO), which is ubiquitously present in living organisms, regulates many developmental and stress-activated processes in plants. Regulatory effects exerted by NO lies mostly in its chemical reactivity as a free radical. Proteins are… read more here.
Keywords: site; protein tyrosine; tyrosine nitration; nitric oxide ... See more keywords
Short-Term Low Temperature Induces Nitro-Oxidative Stress that Deregulates the NADP-Malic Enzyme Function by Tyrosine Nitration in Arabidopsis thaliana
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DOI: 10.3390/antiox8100448
Abstract: Low temperature (LT) negatively affects plant growth and development via the alteration of the metabolism of reactive oxygen and nitrogen species (ROS and RNS). Among RNS, tyrosine nitration, the addition of an NO2 group to… read more here.
Keywords: nitration; tyrosine nitration; stress; short term ... See more keywords