Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800529
Abstract: A highly selective detection method of native protein tyrosine phosphatase 1B (PTP1B) is described using a target specific probe equipped with 1‐naphthylamine (λex=330 nm, λem=445 nm). Irradiation of a mixture of PTP1B and Probe 1 with ultraviolet light…
read more here.
Keywords:
detection;
probe;
tyrosine phosphatase;
protein tyrosine ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32555
Abstract: Background and Aims: SH2 domain–containing protein tyrosine phosphatase 2 (Shp2) is the first identified pro‐oncogenic tyrosine phosphatase that acts downstream of receptor tyrosine kinases (RTKs) to promote Ras–extracellular signal–regulated kinase signaling. However, this phosphatase was…
read more here.
Keywords:
inhibition;
shp2;
phosphatase;
metastasized liver ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23554
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive tumor with a dismal prognosis. Recent studies have demonstrated PTPN2 (protein tyrosine phosphatase nonreceptor type 2) as a potential target for cancer therapy. However, the functions of…
read more here.
Keywords:
protein tyrosine;
nonreceptor type;
phosphatase nonreceptor;
ductal adenocarcinoma ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02762-1
Abstract: Chemical investigation of Phaeophytan marine macroalga Turbinaria ornata (family Sargassaceae) resulted in the characterization of three 2-furanone analogues, which were characterized as 6, 7-dihydroxy-8-methyl-3-(5′-methyloct-4′-en-1′-yl)-hexahydrocyclooct-1-en-[1, 2-c]furan-11-one (turbinafuranone A), 4-hydroxy-3-isopropyl-7, 8-dimethyl-6-(pentan-2′-acetate)-hexahydrocycloocta-1-en-[1, 2-c]furan-11-one (turbinafuranone B), and 6-acetoxy-8-ethyl-5-methoxy-3-(2′-methylhex-4′-en-1′-yl)-pentahydrocycloocta-1, 7-dien-[1,…
read more here.
Keywords:
turbinafuranone;
tyrosine phosphatase;
turbinaria ornata;
marine macroalga ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2019 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-019-02657-z
Abstract: Polysaccharide fractions were sequentially extracted in 28.86 wt% yield from roots of Ferula sinkiangensis K. M. Shen. The polysaccharide fractions from F. sinkiangensis were identified as heteropolysaccharides and contained primarily the monosaccharides glucuronic and galacturonic…
read more here.
Keywords:
ferula sinkiangensis;
polysaccharide fractions;
tyrosine phosphatase;
protein tyrosine ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05637-z
Abstract: BackgroundThe protein tyrosine phosphatase delta (PTPRD) is a tumor suppressor, and its role in gastric cancer (GC) remains poorly understood.MethodsThe expressions of PTPRD were determined based on public data. In addition, the mRNA expressions of…
read more here.
Keywords:
signal transducer;
gastric cancer;
transducer activator;
tyrosine phosphatase ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10323-2
Abstract: Protein tyrosine phosphatase 1B (PTP1B) acts as a therapeutic target for type 2 diabetes. However, the major challenges of PTP1B drug discovery are the poor selectivity and the weak oral bioavailability. In this study, we…
read more here.
Keywords:
virtual screening;
tyrosine phosphatase;
combined virtual;
protein tyrosine ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2018 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9770-7
Abstract: The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [13C,15N]-labeled protein. These assignments facilitate further studies of HePTP in the…
read more here.
Keywords:
sequence specific;
tyrosine phosphatase;
tyrosine;
backbone assignment ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-8265-8
Abstract: Although protein tyrosine phosphatases(PTPs) do not contain any metals, their activities can be inhibited by some metal complexes. Here we investigated the inhibition of two zinc complexes with Schiff base ligands against PTPs activity to…
read more here.
Keywords:
phosphatase;
tyrosine phosphatase;
zinc complexes;
protein tyrosine ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.150
Abstract: The metastatic potential of malignant tumor has been shown to be correlated with the increased expression of tri- and tetra-antennary β1,6-N-acetylglucosamine (β1,6-GlcNAc) N-glycans. In this study, We found that GnT-V expression was negatively correlated with…
read more here.
Keywords:
plc pkc;
phosphatase;
tyrosine phosphatase;
pkc pathways ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.075
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a widely expressed 50 kDa enzyme and the first intracellular PTP to be purified from human placental tissue. It has been proved that protein tyrosine phosphatase 1B played a significant…
read more here.
Keywords:
tyrosine phosphatase;
phosphatase ptp1b;
protein tyrosine;
ptp1b ... See more keywords