Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3‐EDT2
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700253
Abstract: Methods for activating signaling enzymes hold significant potential for the study of cellular signal transduction. Here we present a strategy for engineering chemically activatable protein tyrosine phosphatases (actPTPs). To generate actPTP1B, we introduced three cysteine… read more here.
Keywords: tyrosine phosphatases; ascy3 edt2; wpd loop; protein tyrosine ... See more keywords
Mapping the Chemical Space of Active‐Site Targeted Covalent Ligands for Protein Tyrosine Phosphatases **
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200706
Abstract: Protein tyrosine phosphatases (PTPs) are an important class of enzymes that modulate essential cellular processes through protein dephosphorylation and are dysregulated in various disease states. There is demand for new compounds that target the active… read more here.
Keywords: protein tyrosine; mapping chemical; space active; tyrosine phosphatases ... See more keywords
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB Life"
DOI: 10.1002/iub.2716
Abstract: In October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID had disrupted and restricted preparations for the gathering, which ultimately was held… read more here.
Keywords: protein tyrosine; phosphatases mighty; tyrosine phosphatases; mighty oaks ... See more keywords
Nonreceptor protein tyrosine phosphatases (NRPTPs) gene family associates with the risk of hepatocellular carcinoma in a Chinese hepatitis B virus‐related subjects
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23228
Abstract: Nonreceptor protein tyrosine phosphatases (NRPTPs) are reported to be associated with several human cancers, but their roles in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) remain unclear. Here, we integrated bioinformatics tools, population association analyses,… read more here.
Keywords: risk; hcc; tyrosine phosphatases; hbv ... See more keywords
Protein tyrosine phosphatases in cardiac physiology and pathophysiology
Sign Up to like & getrecommendations! Published in 2018 at "Heart Failure Reviews"
DOI: 10.1007/s10741-018-9676-1
Abstract: More than any other organ, the heart is particularly sensitive to gene expression deregulation, often leading in the long run to impaired contractile performances and excessive fibrosis deposition progressing to heart failure. Recent investigations provide… read more here.
Keywords: heart; tyrosine phosphatases; protein tyrosine; pathophysiology ... See more keywords
Genome-wide survey of tyrosine phosphatases in thirty mammalian genomes.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110009
Abstract: The age of genomics has given us a wealth of information and the tools to study whole genomes. This, in turn, has facilitated genome-wide studies among organisms that were relatively less studied in the pre-genomic… read more here.
Keywords: mammalian genomes; genome wide; thirty mammalian; tyrosine phosphatases ... See more keywords
Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00105
Abstract: An appropriate level of protein phosphorylation on tyrosine is essential for cells to react to extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways mediated by protein tyrosine phosphorylation causes numerous human diseases,… read more here.
Keywords: tyrosine phosphatases; regulatory mechanisms; protein tyrosine; therapeutic targeting ... See more keywords
Identification of novel inhibitor of protein tyrosine phosphatases delta: structure-based pharmacophore modeling, virtual screening, flexible docking, molecular dynamics simulation, and post-molecular dynamics analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1682050
Abstract: Abstract Owing to their unique functions in regulating the synapse activity of protein tyrosine phosphatases delta (PTPδ) that has drawn special attention for developing drugs to autism spectrum disorders (ASDs). In this study, the PTPδ… read more here.
Keywords: molecular dynamics; tyrosine phosphatases; phosphatases delta; protein tyrosine ... See more keywords
Ultraviolet Radiation Exposure and its Impacts on Cutaneous Phosphorylation Signaling in Carcinogenesis: Focusing on Protein Tyrosine Phosphatases †
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13703
Abstract: Sunlight exposure is a significant risk factor for UV‐induced deteriorating transformations of epidermal homeostasis leading to skin carcinogenesis. The ability of UVB radiation to cause melanoma, as well as basal and squamous cell carcinomas, makes… read more here.
Keywords: protein tyrosine; tyrosine; tyrosine phosphatases; signaling pathways ... See more keywords
A comprehensive review on the role of protein tyrosine phosphatases in gastric cancer development and progression
Sign Up to like & getrecommendations! Published in 2021 at "Biological Chemistry"
DOI: 10.1515/hsz-2020-0355
Abstract: Abstract The main post-translational reversible modulation of proteins is phosphorylation and dephosphorylation, catalyzed by protein kinases (PKs) and protein phosphatases (PPs) which is crucial for homeostasis. Imbalance in this crosstalk can be related to diseases,… read more here.
Keywords: cancer; gastric cancer; tyrosine phosphatases; protein tyrosine ... See more keywords
Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.608747
Abstract: Early TCR signaling is dependent on rapid phosphorylation and dephosphorylation of multiple signaling and adaptor proteins, leading to T cell activation. This process is tightly regulated by an intricate web of interactions between kinases and… read more here.
Keywords: tyrosine phosphatases; early tcr; autoimmunity; tcr signaling ... See more keywords