SH2 Domain Histochemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6762-9_31
Abstract: Among posttranslational modifications, the phosphorylation of tyrosine residues is a key modification in cell signaling. Because of its biological importance, characterization of the cellular state of tyrosine phosphorylation is of great interest. Based on the… read more here.
Keywords: tyrosine phosphorylation; sh2 domain; phosphorylation; tyrosine ... See more keywords
Src mediates β-adrenergic receptor induced YAP tyrosine phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Science China Life Sciences"
DOI: 10.1007/s11427-020-1652-9
Abstract: The Hippo pathway is a newly identified pathway and evolutionarily conserved from flies to humans mainly regulating cell proliferation. Transcriptional co-activator Yes-associated protein (YAP) functions as a major downstream effector and key node of the… read more here.
Keywords: tyrosine phosphorylation; src; adrenergic receptor; phosphorylation ... See more keywords
Mercury-Induced Inhibition of Tyrosine Phosphorylation of Sperm Proteins and Altered Functional Dynamics of Buck Spermatozoa: an In Vitro Study
Sign Up to like & getrecommendations! Published in 2020 at "Biological Trace Element Research"
DOI: 10.1007/s12011-020-02077-z
Abstract: Present study was undertaken on buck spermatozoa to investigate the effect of mercuric chloride on functional dynamics of buck spermatozoa. Four different concentrations (0.031, 0.125, 0.25 and 1.25 μg/mL) of mercuric chloride, which were 1/40th,… read more here.
Keywords: tyrosine phosphorylation; mercuric chloride; exposure; phosphorylation ... See more keywords
Luteinizing hormone modulates intracellular calcium, protein tyrosine phosphorylation and motility during human sperm capacitation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.010
Abstract: In order to fertilize, spermatozoa must undergo physiological and biochemical changes during their transit along the female reproductive tract before reaching and fusing with the oocyte, process known as capacitation. Sperm modifications associated with capacitation… read more here.
Keywords: hormone; capacitation; protein tyrosine; motility ... See more keywords
Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.130
Abstract: Protein-tyrosine kinases transmit signals by phosphorylating their substrates in diverse cellular events. The receptor-type tyrosine kinase ErbB4, a member of the epidermal growth factor receptor subfamily, is activated and proteolytically cleaved upon ligand stimulation, and… read more here.
Keywords: histone h3k9; trimethylation histone; tyrosine; h3k9me3 ... See more keywords
Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.08.004
Abstract: Retinoic acid-inducible gene I (RIG-I) detects viral RNAs and induces antiviral responses. During viral RNA recognition by RIG-I, tripartite motif protein 25 (TRIM25) plays a critical regulatory role by inducing K63-linked RIG-I polyubiquitination. Previous proteomics… read more here.
Keywords: regulatory role; rig; tyrosine phosphorylation; src ... See more keywords
Anethole compromises human sperm function by affecting the sperm intracellular calcium concentration and tyrosine phosphorylation.
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2020.01.007
Abstract: Anethole is a natural anisole derivative that has been widely used in food and daily chemical industries, agricultural applications and the traditional medicine. It is closely related to aspects of daily life, and humans can… read more here.
Keywords: sperm function; tyrosine phosphorylation; anethole; human sperm ... See more keywords
Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0481-z
Abstract: Protein-tyrosine kinases regulate a broad range of intracellular processes occurring primarily just beneath the plasma membrane. With the greatest care to prevent dephosphorylation, we have shown that nuclear tyrosine phosphorylation regulates global chromatin structural states.… read more here.
Keywords: phosphorylation tif1; tgf signaling; tyrosine phosphorylation; tif1 ... See more keywords
The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis
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DOI: 10.1038/s41388-021-01917-z
Abstract: Cancer metastasis causes >90% of cancer deaths and remains a major treatment challenge. Here we deciphered the impact of tyrosine phosphorylation of MACC1, a causative driver for cancer metastasis, for cancer cell signaling and novel… read more here.
Keywords: macc1; cancer metastasis; metastasis; cancer ... See more keywords
Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion
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DOI: 10.1038/s41598-017-10210-7
Abstract: Dependent on their cellular localization, Protein Kinase D (PKD) enzymes regulate different processes including Golgi transport, cell signaling and response to oxidative stress. The localization of PKD within cells is mediated by interaction with different… read more here.
Keywords: phosphorylation; adhesion; focal adhesions; protein kinase ... See more keywords
Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle
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DOI: 10.1038/s41598-021-82189-1
Abstract: Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has been reported between SFKs and the mitotic spindle; however, the underlying mechanisms… read more here.
Keywords: tyrosine phosphorylation; kinastrin; kinastrin skap; prc1 ... See more keywords