Generation of an Aptamer Targeting Receptor-Type Tyrosine-Protein Phosphatase F.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03988
Abstract: Cell-SELEX is a powerful tool to generate aptamers that specifically bind the native molecules on living cells. Here, we report an aptamer ZAJ4a generated by cell-SELEX. The molecular target of ZAJ4a was pulled down by… read more here.
Keywords: cell; type tyrosine; cell selex; protein phosphatase ... See more keywords
Allosteric inhibition induces an open WPD-loop: a new avenue towards glioblastoma therapy
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DOI: 10.1039/c8ra08427k
Abstract: The mobility of loops around the catalytic site of a protein remains crucial to its activity. Dynamics of the WPD-loop is an essential determinant of the catalytic activity of tyrosine-protein phosphatase zeta, an implicated protein… read more here.
Keywords: protein; phosphatase zeta; wpd loop; tyrosine protein ... See more keywords
Apoptosis regulation by the tyrosine-protein kinase CSK
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1078180
Abstract: C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. Current knowledge on the CSK mechanisms… read more here.
Keywords: apoptosis; csk; regulation; tyrosine protein ... See more keywords