Radiometal-Containing Aryl Diazonium Salts for Chemoselective Bioconjugation of Tyrosine Residues
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b03248
Abstract: Tyrosine is an attractive target for chemo- and site-selective protein modification. The particular chemical nature of tyrosine residues allows bioconjugation chemistry with reactive aryl diazonium salts via electrophilic aromatic substitution to produce diazo compounds. In… read more here.
Keywords: chemistry; tyrosine; tyrosine residues; 64cu 68ga ... See more keywords
Synthesis of Multi-Protein Complexes through Charge-Directed Sequential Activation of Tyrosine Residues.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c03079
Abstract: Site-selective protein-protein coupling has long been a goal of chemical biology research. In recent years, that goal has been realized to varying degrees through a number of techniques, including the use of tyrosinase-based coupling strategies.… read more here.
Keywords: protein; tyrosine residues; directed sequential; sequential activation ... See more keywords
Recognition of proximally phosphorylated tyrosine residues and continuous analysis of phosphatase activity using a stable europium complex
Sign Up to like & getrecommendations! Published in 2018 at "Supramolecular Chemistry"
DOI: 10.1080/10610278.2017.1410548
Abstract: Abstract The recognition of proteins and their post-translational modifications using synthetic molecules is an active area of research. A common post-translational modification is the phosphorylation of serine, threonine or tyrosine residues. The phosphorylation of proximal… read more here.
Keywords: proximally phosphorylated; europium; recognition; tyrosine residues ... See more keywords