Modulating tyrosine sulfation of recombinant antibodies in CHO cell culture by host selection and sodium chlorate supplementation
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DOI: 10.1002/biot.202100142
Abstract: Tyrosine sulfation is a post‐translational modification found on many surface receptors and plays an important role in cell‐cell and cell‐matrix interactions. However, tyrosine sulfation of therapeutic antibodies has only been reported very recently. Because of… read more here.
Keywords: tyrosine sulfation; modulating tyrosine; sulfation; recombinant antibodies ... See more keywords
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
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DOI: 10.1042/bcj20180266
Abstract: Protein tyrosine sulfation is a post-translational modification best known for regulating extracellular protein–protein interactions. Tyrosine sulfation is catalysed by two Golgi-resident enzymes termed tyrosylprotein sulfotransferases (TPSTs) 1 and 2, which transfer sulfate from the cofactor… read more here.
Keywords: kinase inhibitors; tyrosine sulfation; sulfation; protein kinase ... See more keywords