Corrigendum to "A continuous tyrosyl-tRNA synthetase assay that regenerates the tRNA substrate" [Anal. Biochem. 486 (2015) 86-95].
Sign Up to like & getrecommendations! Published in 2017 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2016.11.002
Abstract: The authors regret that in Figure 3 panels B and D, Figure 5 panels B and D, and Figure 6 panel D, kobs (i.e., v0/[Enzyme]) is plotted on the y-axis rather than v0, as indicated… read more here.
Keywords: synthetase assay; trna synthetase; corrigendum continuous; continuous tyrosyl ... See more keywords
Novel partial loss-of-function variants in the tyrosyl-tRNA synthetase 1 (YARS1) gene involved in multisystem disease.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2021.104294
Abstract: Cytoplasmic aminoacyl-tRNA synthetases (ARSs) are emerging as a cause of numerous rare inherited diseases. Recently, biallelic variants in tyrosyl-tRNA synthetase 1 (YARS1) have been described in ten patients of three families with multi-systemic disease (failure… read more here.
Keywords: variants tyrosyl; synthetase yars1; yars1; trna synthetase ... See more keywords
New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies
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DOI: 10.1038/s41598-017-10618-1
Abstract: Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be… read more here.
Keywords: synthase inhibitors; comsia; trna synthase; tyrosyl trna ... See more keywords
Thermodynamic Analysis of Tyrosyl-tRNA Synthetases Revealed Bacterial-Selective Tyrosine Derivatives
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DOI: 10.1071/ch21218
Abstract: The non-proteinogenic amino acids m-fluorotyrosine and 2,4-dihydroxyphenylalanine demonstrated a respective 6- and 12-fold greater binding affinity to the purified tyrosyl-tRNA synthetase from Escherichia coli than that from human cytosol. The differential binding was identified by… read more here.
Keywords: thermodynamic analysis; synthetases revealed; analysis tyrosyl; revealed bacterial ... See more keywords
Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212659119
Abstract: Significance Infection is often associated with thrombocytopenia and rapid replenishment of platelets may be important to maintain vascular homeostasis. We found that an activated form of tyrosyl-tRNA synthetase (YRSACT) mimics inflammatory stress in mice, inducing… read more here.
Keywords: tyrosyl trna; viral infection; trna synthetase; infection ... See more keywords
Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease
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DOI: 10.1093/hmg/ddy344
Abstract: Aminoacyl-tRNA synthetases (ARSs) are critical for protein translation. Pathogenic variants of ARSs have been previously associated with peripheral neuropathy and multisystem disease in heterozygotes and homozygotes, respectively. We report seven related children homozygous for a… read more here.
Keywords: disease; synthetase yars; trna synthetase; tyrosyl trna ... See more keywords
Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography
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DOI: 10.3390/ijms231810399
Abstract: Genetically encoded caged amino acids can be used to control the dynamics of protein activities and cellular localization in response to external cues. In the present study, we revealed the structural basis for the recognition… read more here.
Keywords: tyrosyl trna; time; resolved ray; trna synthetase ... See more keywords
Synthesis, Molecular Docking and Characterization of Pyrazole N-Mannich Base Derivatives as Antimicrobial Agents
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DOI: 10.52711/0974-360x.2023.00175
Abstract: In this work we aimed to design synthesis and evaluate the N-Mannich bases of pyrazole. A novel series of N-Mannich bases of pyrazole analogues were designed and synthesized with an effort to overcome the increasing… read more here.
Keywords: molecular docking; tyrosyl trna; trna synthetase; synthesis ... See more keywords