In vitro characterization of the intramelanosomal domain of human recombinant TYRP1 and its oculocutaneous albinism type 3‐related mutant variants
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DOI: 10.1002/pro.4518
Abstract: Tyrosinase related protein 1 (TYRP1) is the most abundant melanosomal protein of the melanocyte, where plays an important role in the synthesis of eumelanin, possibly catalyzing the oxidation of 5,6‐dihydroxyindole‐2‐carboxylic acid to 5,6‐quinone‐2‐carboxylic acid. Mutations… read more here.
Keywords: tyrp1; domain; intramelanosomal domain; oculocutaneous albinism ... See more keywords
A non-coding function of TYRP1 mRNA promotes melanoma growth
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DOI: 10.1038/ncb3623
Abstract: Competition among RNAs to bind miRNA is proposed to influence biological systems. However, the role of this competition in disease onset is unclear. Here, we report that TYRP1 mRNA, in addition to encoding tyrosinase-related protein… read more here.
Keywords: tyrp1 mrna; coding function; tyrp1; non coding ... See more keywords
TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
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DOI: 10.1080/09273948.2022.2081862
Abstract: OBJECTIVES This research aimed to dissect the function of TYRP1 and PMEL in glaucomatous animal and cell models. METHODS A chronic ocular hypertension (COH) rat model was induced in the right eyes of rats through… read more here.
Keywords: tyrp1; oxidative stress; apoptosis oxidative; pmel ... See more keywords
Abstract CT207: Phase I trial of vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 (VSV-IFNb-TYRP1) in metastatic ocular melanoma
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DOI: 10.1158/1538-7445.am2023-ct207
Abstract: Oncologic viruses (OV) can induce tumor death through both direct oncolysis and immune-mediated destruction. Our study investigates the use of a novel OV with a Vesicular Stomatitis Virus (VSV) vector modified to express interferon-beta (IFN-b)… read more here.
Keywords: tyrp1; ifnb tyrp1; vsv ifnb; melanoma ... See more keywords