Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00104
Abstract: Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus Monascus, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclear. Here,… read more here.
Keywords: cells triggering; human glioma; u251 cells; triggering ros ... See more keywords
TET1 exerts its tumour suppressor function by regulating autophagy in glioma cells
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20160523
Abstract: DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine, (5hmC) leading to eventual… read more here.
Keywords: glioma; u251 cells; tumour suppressor; expression tet1 ... See more keywords
Expression of eIF4E Gene in Glioma and Its Sensitivity to Oxidative Stress
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DOI: 10.1155/2022/5413035
Abstract: Objective Increased expression of eIF4E has been observed in various cancers, which makes eIF4E an attractive target of anticancer drugs. This study mainly discussed eIF4E gene expression in glioma and its sensitivity to oxidative stress… read more here.
Keywords: sensitivity oxidative; expression; u251 cells; eif4e gene ... See more keywords
Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway
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DOI: 10.3389/fonc.2022.859621
Abstract: Objective To clarify the function and mechanisms of sevoflurane (Sev) on ferroptosis in glioma cells. Methods Different concentrations of Sev were used to treat glioma cells U87 and U251. Ferroptosis inducer Erastin was used to… read more here.
Keywords: chac1; u87 u251; glioma cells; u251 cells ... See more keywords
Treatment of Human Glioblastoma U251 Cells with Sulforaphane and a Peptide Nucleic Acid (PNA) Targeting miR-15b-5p: Synergistic Effects on Induction of Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041299
Abstract: Glioblastoma multiforme (GBM) is a lethal malignant tumor accounting for 42% of the tumors of the central nervous system, the median survival being 15 months. At present, no curative treatment is available for GBM and… read more here.
Keywords: apoptosis; mir 15b; pna a15b; u251 cells ... See more keywords
Overexpression of centrosomal protein 55 regulates the proliferation of glioma cell and mediates proliferation promoted by EGFRvIII in glioblastoma U251 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2017.7573
Abstract: The epidermal growth factor receptor (EGFR) is often amplified in glioma, with the most common extracellular domain mutation being EGFR variant III (EGFRvIII). Abnormal EGFRvIII signaling has been shown to be important in driving tumor… read more here.
Keywords: proliferation glioma; cep55; u251 cells; proliferation ... See more keywords
Suppression of chloride voltage-gated channel 3 expression increases sensitivity of human glioma U251 cells to cisplatin through lysosomal dysfunction
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DOI: 10.3892/ol.2018.8736
Abstract: The mechanism of cisplatin resistance is complex. Previous studies have indicated that chloride voltage-gated channel 3 (CLCN3) is associated with drug resistance; however, the mechanisms are not fully understood. Therefore, the present study explored the… read more here.
Keywords: suppression; glioma; u251 cells; cisplatin ... See more keywords
Lentivirus‑mediated knockdown of chondroitin polymerizing factor inhibits glioma cell growth in vitro.
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DOI: 10.3892/or.2017.5731
Abstract: Glioma is the most common primary tumor in the central nervous system, characterized by rapid progression, aggressive behavior, frequent recurrence and poor prognosis. In the present study we demonstrated that chondroitin polymerizing factor (CHPF) is highly… read more here.
Keywords: glioma; u251 cells; polymerizing factor; glioma cell ... See more keywords