Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
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DOI: 10.1038/ncomms14060
Abstract: Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring spliceosome gene mutations have increased sensitivity to pharmacological perturbation of the spliceosome. We focus on… read more here.
Keywords: u2af1 expressing; mutant u2af1; expressing cells; u2af1 s34f ... See more keywords