A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.
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DOI: 10.1016/j.chembiol.2021.02.007
Abstract: Dysregulated pre-mRNA splicing is an emerging Achilles heel of cancers and myelodysplasias. To expand the currently limited portfolio of small-molecule drug leads, we screened for chemical modulators of the U2AF complex, which nucleates spliceosome assembly… read more here.
Keywords: small molecule; mrna splicing; pre mrna; u2af2 rna ... See more keywords