Methionine sulfoxide reductase B1 regulates proliferation and invasion by affecting mitogen-activated protein kinase pathway and epithelial-mesenchymal transition in u2os cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.151
Abstract: Methionine sulfoxide reductase B1 (MsrB1), a member of the selenoprotein family and contributes significantly to the reduction of methionine sulfoxides produced from reactive oxygen species (ROS). However, few studies have examined the role of MsrB1… read more here.
Keywords: sulfoxide reductase; proliferation invasion; invasion; u2os cells ... See more keywords
PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119556
Abstract: OBJECTIVE Poly(ADP-ribose) polymerase-1 (PARP1) interacts and poly(ADP-ribosyl)ates telomere repeat binding factor 2 (TRF2), which acts as a platform to recruit a large number of proteins at the telomere. Since the discovery of TRF2-SLX4 interaction, SLX4… read more here.
Keywords: telomere localization; slx4; telomere length; u2os cells ... See more keywords
Effect of 17β-estradiol on the migration ability of human osteosarcoma U2OS cells
Sign Up to like & getrecommendations! Published in 2018 at "Translational cancer research"
DOI: 10.21037/24598
Abstract: Background: To investigate the effect of 17β-estradiol on the migration ability of human osteosarcoma U2OS cells. Methods: Six concentrations of 17β-estradiol were tested in the U2OS cells, and the minimum concentration that could significantly affect… read more here.
Keywords: migration ability; u2os cells; effect estradiol; test ... See more keywords
Colchicine as a novel drug for the treatment of osteosarcoma through drug repositioning based on an FDA drug library
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.893951
Abstract: Background Colchicine is a traditional medication that is currently approved to treat gout and familial Mediterranean fever (FMF). However, colchicine has a wide range of anti-inflammatory activities, and several studies have indicated that it may… read more here.
Keywords: u2os cells; colchicine; saos u2os; treatment ... See more keywords
17β‑Estradiol treatment drives Sp1 to upregulate MALAT‑1 expression and epigenetically affects physiological processes in U2OS cells.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6115
Abstract: Osteosarcoma is the most common primary bone tumor characterized by high risk of metastasis, thus presents with an overall survival rate of 60%, despite the use of chemotherapy and surgery. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT‑1)… read more here.
Keywords: malat expression; physiological processes; treatment; malat promoter ... See more keywords
Downregulation of calbindin 1, a calcium-binding protein, reduces the proliferation of osteosarcoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5931
Abstract: Osteosarcoma is the most common type of primary malignant bone tumor and has a high propensity to metastasize to the lungs and bones. Calbindin 1 (CALB1) is a constituent Ca2+ binding protein, which can prevent… read more here.
Keywords: calb1; u2os cells; binding protein; osteosarcoma cells ... See more keywords
Propofol inhibits the malignant development of osteosarcoma U2OS cells via AMPK/FΟΧO1-mediated autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13430
Abstract: It has previously been reported that propofol regulates the development of human osteosarcoma (OS). However, the specific molecular mechanisms underlying the effect of propofol on OS remain poorly understood. Therefore, the aim of the present… read more here.
Keywords: cell; development; propofol; via ampk ... See more keywords