Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23797
Abstract: Glioblastoma (GBM) is classified as a stage-IV glioma. Unfortunately, there are currently no curative treatments for GBM. Poly(rC)-binding protein 1 (PCBP1) is a cytosolic iron chaperone with diverse functions. PCBP1 is also known to regulate… read more here.
Keywords: cell; pcbp1; iron chaperone; u87 cells ... See more keywords
LRRC8A potentiates temozolomide sensitivity in glioma cells via activating mitochondria-dependent apoptotic pathway
Sign Up to like & getrecommendations! Published in 2018 at "Human Cell"
DOI: 10.1007/s13577-018-0221-2
Abstract: Chloride (Cl−), a primary anion in the extracellular fluid, plays an important role in a variety of physiological and pathological processes, such as cell apoptosis and proliferation. However, the information about Cl− in cancer cell… read more here.
Keywords: u87 cells; apoptosis; lrrc8a; mitochondria dependent ... See more keywords
Nociceptin/orphanin FQ antagonizes lipopolysaccharide‐stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.05.021
Abstract: &NA; Glioblastoma is among the most aggressive brain tumors and has an exceedingly poor prognosis. Recently, the importance of the tumor microenvironment in glioblastoma cell growth and progression has been emphasized. Toll‐like receptor 4 (TLR4)… read more here.
Keywords: u87 cells; bgr; glioblastoma; proliferation ... See more keywords
Globularifolin exerts anticancer effects on glioma U87 cells through inhibition of Akt/mTOR and MEK/ERK signaling pathways in vitro and inhibits tumor growth in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.09.005
Abstract: Gliomas are the most recurrently occurring primary malignancies in the central nervous system. Despite surgical interventions, chemo- and radiotherapy, the results are unfortunately poor. Therefore, there is pressing need to explore more effective and efficient… read more here.
Keywords: u87 cells; inhibition akt; globularifolin; glioma ... See more keywords
Demethoxycurcumin mediated targeting of MnSOD leading to activation of apoptotic pathway and inhibition of Akt/NF‐&kgr;B survival signalling in human glioma U87 MG cells
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.02.020
Abstract: ABSTRACT Earlier, we reported that Demethoxycurcumin (DMC) suppressed the growth of human glioma U87 MG cells by downregulation of Bcl‐2 expression. In the present work, we investigated the DMC induced reactive oxygen species (ROS) mediated… read more here.
Keywords: u87 cells; inhibition; activation; mnsod ... See more keywords
Exploring the cytotoxicity and anticancer effects of doxycycline and azithromycin on human glioblastoma multiforme cells.
Sign Up to like & getrecommendations! Published in 2021 at "Neurological research"
DOI: 10.1080/01616412.2021.1975225
Abstract: BACKGROUND Previous studies had reported on the cytotoxic activities of generic antibiotics such as doxycycline (DOXY) and azithromycin (AZI) in multiple types of human cancers. Given that resistance to standard anti-glioblastoma multiforme (GBM) drug [temozolomide… read more here.
Keywords: u87 cells; cytotoxicity anticancer; glioblastoma multiforme; anticancer effects ... See more keywords
Impact of extremely low-frequency electromagnetic field (100 Hz, 100 G) exposure on human glioblastoma U87 cells during Temozolomide administration
Sign Up to like & getrecommendations! Published in 2019 at "Electromagnetic Biology and Medicine"
DOI: 10.1080/15368378.2019.1625784
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is a highly malignant brain tumor with an extremely dismal prognosis, a median survival is12 months. Temozolomide (TMZ) is an alkylating agent widely used to treat cancer, resistance to this drug… read more here.
Keywords: 100 100; u87 cells; glioblastoma; glioblastoma u87 ... See more keywords
The Therapeutic Potential of Aprepitant in Glioblastoma Cancer Cells through Redox Modification
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/8540403
Abstract: Although there is no doubt regarding the involvement of oxidative stress in the development of glioblastoma, many questions remained unanswered about signaling cascades that regulate the redox status. Given the importance of the substance P… read more here.
Keywords: glioblastoma; therapeutic potential; oxidative stress; u87 cells ... See more keywords
Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0397-7
Abstract: BackgroundGlioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its inevitable recurrence is frequently explained by the presence of cancer stem cells. We aimed to show that human GBM cells with… read more here.
Keywords: u87 cells; cell; gbm cells; cells stemness ... See more keywords
Apoptotic Effects of N-(2-hydroxyphenyl)-2-propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200728125356
Abstract: BACKGROUND AND OBJECTIVE Histone deacetylases (HDACs) are important therapeutic targets for many types of human cancers. A derivative of valproic acid, N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), has antiproliferative properties on some cancer cell lines and inhibits the HDAC1… read more here.
Keywords: u87 cells; antiangiogenic properties; hydroxyphenyl propylpentanamide; aavpa antiproliferative ... See more keywords
Strengthening Anti-Glioblastoma Effect by Multi-Branched Dendrimers Design of a Scorpion Venom Tetrapeptide
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030806
Abstract: Glioblastoma is the most aggressive and invasive form of central nervous system tumors due to the complexity of the intracellular mechanisms and molecular alterations involved in its progression. Unfortunately, current therapies are unable to stop… read more here.
Keywords: effect; branched aats; multi branched; u87 cells ... See more keywords