Articles with "ubc12 interaction" as a keyword



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Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.

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Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113326

Abstract: Defective in cullin neddylation 1(DCN1) is a co-E3 ligase that is important for cullin neddylation. Dysregulation of DCN1 highly correlates with the development of various cancers. Herein, from the initial high-throughput screening, a novel hit… read more here.

Keywords: phenyltriazole thiol; dcn1 ubc12; development; ubc12 interaction ... See more keywords