Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways.
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DOI: 10.1093/hmg/ddz221
Abstract: UBE3A encodes a E3 ubiquitin ligase whose loss from the maternal allele causes the neurodevelopmental disorder Angelman syndrome. Previous studies of UBE3A function have not examined full Ube3a deletion in mouse, the complexity of imprinted… read more here.
Keywords: wnt signaling; gene networks; ube3a loss; ube3a deletion ... See more keywords