Targeting BAX ubiquitin‐binding sites reveals that BAX activation is essential for its ubiquitin‐dependent degradation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29505
Abstract: BAX is an important proapoptotic protein of the BCL‐2 family, and its stability is essential for the regulation of the mitochondrial apoptotic pathway. A previous study revealed that BAX could undergo degradation through the ubiquitin‐proteasome… read more here.
Keywords: bax; degradation; ubiquitin binding; binding sites ... See more keywords
USP7 small-molecule inhibitors interfere with ubiquitin binding
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24006
Abstract: The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of ubiquitin modifications regulates substrate interactions with specific proteins. Thus ubiquitination directs a… read more here.
Keywords: small molecule; binding; ubiquitin binding; molecule inhibitors ... See more keywords
SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52408-x
Abstract: The NF-κB pathway is constitutively activated in adult T cell leukemia, an aggressive malignancy caused by Human T Leukemia Virus type 1 (HTLV-1). The viral oncoprotein Tax triggers this constitutive activation by interacting with the… read more here.
Keywords: tax; p62; tax mediated; ubiquitin binding ... See more keywords
LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2024396
Abstract: ABSTRACT Dysregulated long non-coding RNAs (lncRNAs) play an important role in cancer progression. However, there have been limited reports to date of the involvement of ubiquitin-binding protein domain protein 10 antisense RNA 1 (UBXN10-AS1) in… read more here.
Keywords: binding protein; ubiquitin binding; coad; ubxn10 as1 ... See more keywords
A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
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DOI: 10.2210/pdb6h3a/pdb
Abstract: Summary Ubiquitylation, the posttranslational linkage of ubiquitin moieties to lysines in target proteins, helps regulate a myriad of biological processes. Ubiquitin, and sometimes ubiquitin-homology domains, are recognized by ubiquitin-binding domains, including CUE domains. CUE domains are… read more here.
Keywords: domain; cue domains; ubiquitin ubiquitin; ubiquitin binding ... See more keywords
Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1112688
Abstract: Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) diseases that are caused by anomalous CAG triplet repeat expansions in several genes. SCA3 results from abnormal polyQ expansion in the… read more here.
Keywords: atxn3; ubiquitin binding; toxicity; ataxia type ... See more keywords