KBTBD7 promotes non‐small cell lung carcinoma progression by enhancing ubiquitin‐dependent degradation of PTEN
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4794
Abstract: The Kelch repeat and BTB domain containing 7 (KBTBD7) was first cloned in 2010. Its function as a transcriptional activator and a substrate adaptor during the ubiquitination process was soon found. KBTBD7 was shown to… read more here.
Keywords: cell; non small; kbtbd7; small cell ... See more keywords
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.03.017
Abstract: The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral signaling activity of… read more here.
Keywords: immunity; rig; dependent independent; ubiquitin dependent ... See more keywords
Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.013
Abstract: The ubiquitin proteasome system (UPS) regulates many cellular functions by degrading key proteins. Notably, the role of UPS in regulating mitochondrial metabolic functions is unclear. Here, we show that ubiquitination occurs in different mitochondrial compartments,… read more here.
Keywords: dependent degradation; degradation; energy metabolism; ubiquitin dependent ... See more keywords
Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.01.016
Abstract: Cell-cell fusion is a frequent and essential event during development, and its dysregulation causes diseases ranging from infertility to muscle weakness. Fusing cells need to repeatedly remodel their plasma membrane through orchestrated formation and disassembly… read more here.
Keywords: fusion; actin cytoskeleton; cell fusion; ubiquitin dependent ... See more keywords
Ubiquitin-Dependent Regulation of Stem Cell Biology.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.04.002
Abstract: The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or terminally commit to a cell specification program.… read more here.
Keywords: cell biology; stem cell; ubiquitin dependent; biology ... See more keywords
A ubiquitin-dependent signaling axis specific for ALKBH-mediated DNA dealkylation repair
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24484
Abstract: DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms… read more here.
Keywords: alkylating agents; ubiquitin dependent; damage; alkylation ... See more keywords
Principles of Ubiquitin-Dependent Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100617-062802
Abstract: Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin… read more here.
Keywords: ubiquitin dependent; principles ubiquitin; dependent signaling; biology ... See more keywords
A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer"
DOI: 10.1186/s12943-021-01404-9
Abstract: Background Constitutive activation of nuclear factor-κB (NF-κB) signaling plays a key role in the development and progression of colorectal carcinoma (CRC). However, the underlying mechanisms of excessive activation of NF-κB signaling remain largely unknown. Methods… read more here.
Keywords: colorectal carcinoma; ubiquitin dependent; rps3; crc ... See more keywords