DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105226
Abstract: The ability of melanoma to acquire metastasis through the induction of angiogenesis is one of the major causes of skin cancer death. Here, it is found that high transcript levels of DEP domain containing 1B… read more here.
Keywords: metastasis; ubiquitin ligase; depdc1b; scube3 ... See more keywords
Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700128
Abstract: Notch is a mechanosensitive receptor that requires direct cell–cell contact for its activation. Both the strength and the range of notch signaling depend on the size and geometry of the contact sites between cells. These… read more here.
Keywords: cell polarity; ubiquitin ligase; polarity; notch signaling ... See more keywords
The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12334
Abstract: Elucidation of the post‐transcriptional modification has led to novel strategies to treat intractable tumors, especially glioblastoma (GBM). The ubiquitin‐proteasome system (UPS) mediates a reversible, stringent and stepwise post‐translational modification which is closely associated with malignant… read more here.
Keywords: myc dll1; dll1 notch1; ubiquitin ligase; ligase huwe1 ... See more keywords
Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C‐Terminus of Hsc70 Interacting Protein (CHIP)
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DOI: 10.1002/cbic.202100633
Abstract: The ubiquitin ligase C‐terminus of Hsc70 interacting protein (CHIP) is an important regulator of proteostasis. Despite playing an important role in maintaining proteostasis, little progress has been made in developing small molecules that regulate ubiquitin… read more here.
Keywords: ligase; terminus hsc70; ubiquitin ligase; chip ... See more keywords
Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2657
Abstract: Mitochondrial E3 ubiquitin ligase 1 (MUL1) is a mitochondrial outer membrane‐anchored protein‐containing transmembrane domain in its N‐ and C‐terminal regions, where both are exposed to the cytosol. Interestingly the C‐terminal region has a RING finger… read more here.
Keywords: associated mitochondrial; ubiquitin ligase; mitochondrial ubiquitin; mul1 ... See more keywords
Ubiquitin E3 ligase β‐TrCP negatively regulates surface protein of hepatitis B virus
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28620
Abstract: Chronic hepatitis B (CHB) still cannot be cured currently, while the pursuit of a functional cure seems to be an accessible goal, in which the condition mainly depends on the serum hepatitis B surface antigen… read more here.
Keywords: hbsag; trcp; ubiquitin ligase; hbsag levels ... See more keywords
Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms
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DOI: 10.1002/pro.3091
Abstract: The tumor‐suppressor protein BRCA1 works with BARD1 to catalyze the transfer of ubiquitin onto protein substrates. The N‐terminal regions of BRCA1 and BARD1 that contain their RING domains are responsible for dimerization and ubiquitin ligase… read more here.
Keywords: ubiquitin ligase; activity; brca1 bard1;
In vitro ubiquitination of Mycobacterium tuberculosis by E3 ubiquitin ligase, MKRN1
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02873-6
Abstract: Ubiquitination has a role as a host defense mechanism against pathogens. To channelize autophagic mycobacteria to destruction, ubiquitin ligase like, Makorin Ring Finger Protein 1 (MKRN1) was speculated to play a role in ubiquitinating M.… read more here.
Keywords: ubiquitin ligase; mkrn1; tuberculosis; role ... See more keywords
A U-box E3 ubiquitin ligase OsPUB67 is positively involved in drought tolerance in rice
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DOI: 10.1007/s11103-019-00933-8
Abstract: Key message OsPUB67, a U-box E3 ubiquitin ligase, may interact with two drought tolerance negative regulators (OsRZFP34 and OsDIS1) and improve drought tolerance by enhancing the reactive oxygen scavenging ability and stomatal closure. Abstract E3… read more here.
Keywords: box ubiquitin; ospub67; tolerance; ubiquitin ligase ... See more keywords
An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-021-01860-4
Abstract: Glioma is highly lethal because of its high malignancy. Ubiquitination, a type of ubiquitin-dependent protein modification, has been reported to play an oncogenic or tumor-suppressive role in glioma development, depending on the targets. Ring finger… read more here.
Keywords: rnf139; tumor suppressor; ubiquitin ligase; glioma ... See more keywords
Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.127
Abstract: White adipose tissue (WAT) is not only the main tissue for energy storage but also an endocrine organ that secretes adipokines. Obesity is the most common metabolic disorder and is related to alterations in WAT… read more here.
Keywords: ubiquitin ligase; wwp1; obesity; ligase ... See more keywords