Yeast chaperones and ubiquitin ligases contribute to proteostasis during arsenite stress by preventing or clearing protein aggregates.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14638
Abstract: Arsenite causes proteotoxicity by targeting nascent proteins for misfolding and aggregation. Here, we assessed how selected yeast chaperones and ubiquitin ligases contribute to proteostasis during arsenite stress. Loss of the ribosome-associated chaperones Zuo1, Ssz1, and… read more here.
Keywords: proteostasis arsenite; yeast chaperones; arsenite stress; ubiquitin ligases ... See more keywords
E3 ubiquitin ligases and cerebral cortex development in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22877
Abstract: Cerebral cortex development involves the sequential progression of biological steps driven by molecular pathways whose tight regulation often relies on ubiquitination. Ubiquitination is a posttranslational modification involved in all aspects of cellular homeostasis through the… read more here.
Keywords: cerebral cortex; development; ligases cerebral; ubiquitin ligases ... See more keywords
Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6527-4_22
Abstract: The family of seven-in-absentia (SIAH) ubiquitin E3 ligases functions in the control of numerous key signaling pathways. These enzymes belong to the RING (really interesting new gene) group of E3 ligases and mediate the attachment… read more here.
Keywords: acetyl transferases; effects siah; testing effects; ubiquitin ligases ... See more keywords
Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_19
Abstract: Cullin-RING ligases (CRLs), the largest family of E3 ubiquitin ligases, have become an attractive target for drug discovery, primarily due to their ability to regulate the degradation of numerous functionally and structurally diverse proteins, thereby… read more here.
Keywords: cullin ring; ring ubiquitin; targeting cullin; ubiquitin ligases ... See more keywords
Assembly and Regulation of CRL Ubiquitin Ligases.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_3
Abstract: Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for… read more here.
Keywords: protein; assembly regulation; cullin; crl ... See more keywords
Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_5
Abstract: The cullin-RING ubiquitin ligases comprise the largest subfamily of ubiquitin ligases. They control ubiquitylation and degradation of a large number of protein substrates in eukaryotes. p97 is an ATPase domain-containing protein segregase. It plays essential… read more here.
Keywords: cullin ring; ring ubiquitin; ubiquitin ligases; coordinated actions ... See more keywords
Viral Manipulations of the Cullin-RING Ubiquitin Ligases.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_7
Abstract: Cullin-RING ubiquitin ligases (CRLs) are efficient and diverse toolsets of the cells to regulate almost every biological process. However, these characteristics have also been usurped by many viruses to optimize for their replication. CRLs are… read more here.
Keywords: cullin ring; viral manipulations; ring ubiquitin; ubiquitin ligases ... See more keywords
E3 ubiquitin ligases in cancer and implications for therapies
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9703-z
Abstract: E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their degradation, which are of importance in cellular homeostasis. Since many oncogenic or tumor-suppressive proteins are reported to be regulated by… read more here.
Keywords: cancer implications; ubiquitin ligases; implications therapies; cancer ... See more keywords
Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2018.08.001
Abstract: Ubiquitin-proteasome system (UPS) is a primary signaling pathway for regulation of protein turnover and removal of misfolded proteins in eukaryotic cells. Enzymes of the UPS pathway - E1 activating, E2 conjugating, E3 ligating - act… read more here.
Keywords: ring type; type ubiquitin; inflammation immunity; ubiquitin ligases ... See more keywords
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal‐Center Reaction
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.03.006
Abstract: &NA; Selective expansion of high‐affinity antigen‐specific B cells in germinal centers (GCs) is a key event in antibody affinity maturation. GC B cells with improved affinity can either continue affinity‐driven selection or exit the GC… read more here.
Keywords: degradation; expansion; cbl ubiquitin; affinity ... See more keywords
Regulation of T helper cell differentiation by E3 ubiquitin ligases and deubiquitinating enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2016.11.013
Abstract: CD4 T cells are essential components of adaptive immunity and play a critical role in anti-pathogenic or anti-tumor responses as well as autoimmune and allergic diseases. Naive CD4 T cells differentiate into distinct subsets of… read more here.
Keywords: cell differentiation; ligases deubiquitinating; ubiquitin ligases; differentiation ... See more keywords