The ubiquitin‐like protein Hub1/UBL‐5 functions in pre‐mRNA splicing in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14555
Abstract: The ubiquitin‐like protein Hub1/UBL‐5 associates with proteins non‐covalently. Hub1 promotes alternative splicing and splicing of precursor mRNAs with weak introns in yeast and mammalian cells; however, its splicing function has remained elusive in multicellular organisms.… read more here.
Keywords: hub1; protein hub1; ubiquitin like; caenorhabditis elegans ... See more keywords
Evidence for an involvement of the ubiquitin‐like modifier ISG15 in MHC class I antigen presentation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048646
Abstract: The IFN stimulated gene 15 (ISG15) encodes a 15‐kDa ubiquitin‐like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an… read more here.
Keywords: presentation; ubiquitin like; isg15; antigen presentation ... See more keywords
Antibodies to small ubiquitin-like modifier activating enzyme are associated with a diagnosis of dermatomyositis: results from an unselected cohort
Sign Up to like & getrecommendations! Published in 2018 at "Immunologic Research"
DOI: 10.1007/s12026-018-9006-7
Abstract: The aim of this study was to examine the frequency and significance of antibodies targeting the small ubiquitin-like modifier 1 activating enzyme (SAE) in patients under serologic evaluation for idiopathic inflammatory myopathies. Patient sera (n = 17)… read more here.
Keywords: ubiquitin like; small ubiquitin; like modifier; activating enzyme ... See more keywords
The emerging roles of ubiquitin-like protein Urm1 in eukaryotes.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109946
Abstract: The ubiquitin related modifier Urm1 protein was firstly identified in the yeast Saccharomyces cerevisiae, and was later found to play important roles in different eukaryotes. By the assistance of an E1-like activation enzyme Uba4, Urm1… read more here.
Keywords: protein; ubiquitin like; protein urm1; emerging roles ... See more keywords
The prokaryotic ubiquitin-like protein presents poor cleavage sites for proteasomal degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109428
Abstract: In an event reminiscent of eukaryotic ubiquitination, the bacterial prokaryotic ubiquitin-like protein (Pup)-proteasome system (PPS) marks target proteins for proteasomal degradation by covalently attaching Pup, the bacterial tagging molecule. Yet, ubiquitin is released from its… read more here.
Keywords: degradation; ubiquitin like; cleavage; like protein ... See more keywords
Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.03.025
Abstract: Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole… read more here.
Keywords: ubiquitin like; serine 119; like protein; tuberculosis ... See more keywords
Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114227
Abstract: SUMOylation is a key post-translational modification that involves the covalent attachment of small ubiquitin-like modifier (SUMO) to the lysine residues of target proteins. The well-balanced SUMOylation is essential for normal cellular behaviors, while disturbance of… read more here.
Keywords: cancers diseases; small ubiquitin; like modifier; ubiquitin like ... See more keywords
GW28-e0140 Knockout of Small Ubiquitin-Like Modifier 1 Protects the Mice from Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.014
Abstract: Small ubiquitin-like modifier (SUMO1-3) conjugation (SUMOylation), a post-translational modification, modulates activity of a large number of nuclear proteins, including transcriptional factors and chromatin-associated proteins, and plays a crucial role in heart development and pathogenesis of… read more here.
Keywords: e0140 knockout; ubiquitin like; small ubiquitin; like modifier ... See more keywords
Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.04.002
Abstract: JAMM/MPN+ metalloproteases cleave (iso)peptide bonds C-terminal to ubiquitin (Ub) and ubiquitin-like protein (Ubl) domains and typically require association with protein partners for activity, which has limited a molecular understanding of enzyme function. To provide an… read more here.
Keywords: mpn proteases; ubiquitin like; jamm mpn; like protein ... See more keywords
Emerging Roles of Ubiquitin-like Proteins in Pre-mRNA Splicing.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2018.09.001
Abstract: Ubiquitin-like proteins (UBLs) belong to the protein family whose members share a globular beta-grasp fold structure. The archetypal member, ubiquitin, is known for its function in proteasome-mediated protein degradation. UBLs have been shown to play… read more here.
Keywords: like proteins; ubiquitin like; emerging roles; mrna splicing ... See more keywords
Detecting Active Deconjugating Enzymes with Genetically Encoded Activity-Based Ubiquitin and Ubiquitin-like Protein Probes.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03270
Abstract: Post-translational modification of proteins by Ubiquitin (Ub) and Ubiquitin-like proteins (Ubls) can be reversed by deconjugating enzymes, which have been implicated in different pathways and associated with various human diseases. To understand the activity and… read more here.
Keywords: ubl probes; ubiquitin like; genetically encoded; activity ... See more keywords