Alterations in ubiquitin‐mediated degradation of NaV1.5 can cause arrhythmia
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologica"
DOI: 10.1111/apha.13459
Abstract: The voltage-gated sodium (NaV ) channel is required for cardiomyocyte function. In heart, its major, pore-forming, α-subunit is NaV 1.5, encoded by SCN5A, which maps to chromosome 3p21. The NaV channel plays a key role… read more here.
Keywords: cause arrhythmia; ubiquitin mediated; degradation nav1; alterations ubiquitin ... See more keywords
Erythropoiesis signature and ubiquitin‐mediated proteolysis are enriched in systematic juvenile idiopathic arthritis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12573
Abstract: Systemic Juvenile Idiopathic Arthritis (sJIA) is a distinctive subtype of Juvenile Idiopathic Arthritis (JIA). The pathogenesis of sJIA is still unclear with the limited treatment options. Although previous bioinformatics analyses have identified some genetic factors… read more here.
Keywords: ubiquitin mediated; idiopathic arthritis; mediated proteolysis; juvenile idiopathic ... See more keywords
CDK7 inhibition synergizes with topoisomerase I inhibition in small cell lung cancer cells by inducing ubiquitin-mediated proteolysis of RNA polymerase II.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0891
Abstract: Small-cell lung cancers (SCLCs) are highly aggressive and currently there are no available targeted therapies. To identify clinically actionable drug combinations, we analyzed our previously reported chemogenomics screens and identified a synergistically cytotoxic combination of… read more here.
Keywords: ubiquitin mediated; inhibition; rna polymerase; small cell ... See more keywords
Abstract 3964: APE1 protects SMAD3 against ROC1 ubiquitin mediated degradation in esophageal adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3964
Abstract: Background: The incidence of esophageal adenocarcinoma (EAC) has increased more than six-fold over the past three decades and continues to rise in the Western world. The 5-year survival rate for EAC patients is less than… read more here.
Keywords: protects smad3; ape1; ubiquitin mediated; esophageal adenocarcinoma ... See more keywords
Ubiquitin-mediated regulation of autophagy
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DOI: 10.1186/s12929-019-0569-y
Abstract: Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis. Another prime degradation pathway in the cells is ubiquitin-proteasome… read more here.
Keywords: ubiquitin mediated; degradation; mediated regulation; regulation autophagy ... See more keywords
Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.903995
Abstract: This study aimed to understand cold stress adaptations mechanism in fish. Thus, the transcriptional response to cold conditions in Gymnocypris eckloni was evaluated using RNA-seq and microRNA (miRNA)-seq analyses. Low-temperature (LT) group G. eckloni was… read more here.
Keywords: ubiquitin mediated; mirna mrna; gymnocypris eckloni; mediated proteolysis ... See more keywords