Targeting the ubiquitin‐proteasome system in a pancreatic cancer subtype with hyperactive MYC
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12835
Abstract: The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC‐active PDAC may lead to… read more here.
Keywords: pdac; hyperactive myc; proteasome system; myc ... See more keywords
Inhibitors of the ubiquitin proteasome system block myofibril assembly in cardiomyocytes derived from chick embryos and human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Cytoskeleton"
DOI: 10.1002/cm.21697
Abstract: Details of sarcomeric protein assembly during de novo myofibril formation closely resemble myofibrillogenesis in skeletal and cardiac myocytes in birds, rodents, and zebrafish. The arrangement of proteins during myofibrillogenesis follows a three‐step process: beginning with… read more here.
Keywords: myofibril; ubiquitin proteasome; human cardiomyocytes; cardiomyocytes derived ... See more keywords
By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-38266-7_13
Abstract: Primary cilia are microtubule-based sensory organelles that are involved in the organization of numerous key signals during development and in differentiated tissue homeostasis. In fact, the formation and resorption of cilia highly depends on the cell… read more here.
Keywords: ciliogenesis retina; ciliogenesis; tips cilia; retina ubiquitin ... See more keywords
Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-6955-0_19
Abstract: Proper regulation of DNA replication ensures the faithful transmission of genetic material essential for optimal cellular and organismal physiology. Central to this regulation is the activity of a set of enzymes that induce or reverse… read more here.
Keywords: dna replication; proteasome system; replication; regulation ... See more keywords
Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03076-2
Abstract: Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or chemical inhalation exposure. Diacetyl (DA; 2,3-butanedione) is a highly reactive alpha-diketone known to cause BO when… read more here.
Keywords: bronchiolitis obliterans; proteasome stress; exposure; pathology ... See more keywords
The Role of the Ubiquitin Proteasome System in Glioma: Analysis Emphasizing the Main Molecular Players and Therapeutic Strategies Identified in Glioblastoma Multiforme.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02339-4
Abstract: Gliomas constitute the most frequent tumors of the brain. High-grade gliomas are characterized by a poor prognosis caused by a set of attributes making treatment difficult, such as heterogeneity and cell infiltration. Additionally, there is… read more here.
Keywords: proteasome system; role ubiquitin; system; ubiquitin proteasome ... See more keywords
Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2017.09.001
Abstract: The ubiquitin-proteasome pathway (UPP) is a major venue for controlled intracellular protein degradation in Eukaryota. The machinery of several hundred proteins is involved in recognizing, tagging, transporting, and cleaving proteins, all in a highly regulated… read more here.
Keywords: protein; protein interactions; proteasome pathway; protein protein ... See more keywords
Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.06.001
Abstract: Multiple myeloma (MM) is the second most common hematological malignancy and results from the clonal amplification of plasma cells. Despite recent advances in treatment, MM remains incurable with a median survival time of only 5-6years,… read more here.
Keywords: cross talk; multiple myeloma; proteasome system; biology ... See more keywords
Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.039
Abstract: Argonaute (AGO) proteins play a central role in the RNA interference (RNAi) pathway, which is a cytoplasmic mechanism important for post-transcriptional regulation of gene expression. In Drosophila, AGO2 also functions in the nucleus to regulate… read more here.
Keywords: ago2 protein; proteasome pathway; turnover; drosophila argonaute2 ... See more keywords
SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109686
Abstract: In cancers, apoptosis evasion through dysregulation of pro-apoptotic and anti-apoptotic intracellular signals is a recurring event. Accordingly, selective inhibition of specific proteins represents an exciting therapeutic opportunity. Myeloid cell leukemia 1 (MCL1) is an anti-apoptotic… read more here.
Keywords: protein; sumoylation mcl1; proteasome pathway; mcl1 ... See more keywords
New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.013
Abstract: The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with… read more here.
Keywords: iii dithiocarbamate; gold iii; proteasome pathway; dithiocarbamate complex ... See more keywords