Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.029
Abstract: Cancer stem-like cells (CSCs) are regarded as sources of tumorigenesis, metastasis, and drug resistance, which limits current cancer therapies. Elucidating the molecular modes governing CSC properties is necessary to optimize therapeutic approaches. In this study,… read more here.
Keywords: stemness; ligase e3c; cancer; p53 ... See more keywords
Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121478119
Abstract: Significance The mitotic checkpoint system is essential for the prevention of mistakes in the segregation of chromosomes in mitosis. As long as chromosomes are not attached correctly to the mitotic spindle, a mitotic checkpoint complex… read more here.
Keywords: ligase ubr5; mitotic checkpoint; ligase; checkpoint ... See more keywords
Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2052460
Abstract: Mutations in the ubiquitin ligase PRKN (parkin RBR E3 ubiquitin protein ligase) are associated with Parkinson disease and defective mitophagy. Conceptually, PRKN-dependent mitophagy is classified into two phases: 1. PRKN recruits to and ubiquitinates mitochondrial… read more here.
Keywords: ubiquitin protein; prkn parkin; protein ligase; rffl ... See more keywords
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1746148
Abstract: ABSTRACT UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that UBR5 amplifications and overexpression occur in over 20% cases of human breast cancers. Breast cancer patients carrying UBR5 genetic lesions with overexpression… read more here.
Keywords: ubiquitin protein; response; protein ligase; cancer ... See more keywords
The Role of NEDD4 E3 Ubiquitin–Protein Ligases in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030513
Abstract: Parkinson’s disease (PD) is a debilitating neurodegenerative disease that causes a great clinical burden. However, its exact molecular pathologies are not fully understood. Whilst there are a number of avenues for research into slowing, halting,… read more here.
Keywords: protein ligases; ubiquitin protein; disease; parkinson disease ... See more keywords