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   Articles with "ubiquitin specific" as a keyword



Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202307899

Abstract: Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in GC development, immune response, and chemo‐resistance, making it a promising target. Various… read more here.

Keywords: coa desaturase; gastric cancer; ubiquitin specific; stearoyl coa ... See more keywords

Ubiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT

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recommendations! Published in 2019 at "Medical Oncology"

DOI: 10.1007/s12032-019-1308-7

Abstract: Ovarian cancer is one of the most lethal gynecological cancers; owning to its late detection and chemoresistance, understanding the pathogenesis of this malignant tumor is much critical. Previous studies have reported that ubiquitin-specific peptidase 39… read more here.

Keywords: ubiquitin specific; migration; ovarian cancer; human ovarian ... See more keywords
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Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/β-Catenin Signaling

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recommendations! Published in 2021 at "Molecular Biotechnology"

DOI: 10.1007/s12033-021-00330-x

Abstract: Preeclampsia (PE) is a pathologic condition in pregnant women which accounts for the inhibition of proliferation, migration and invasion of trophoblast cells. This study aimed to investigate the regulation of ubiquitin-specific peptidase 5 (USP5) on… read more here.

Keywords: trophoblast cells; ubiquitin specific; catenin; proliferation trophoblast ... See more keywords

Regulation of T cell differentiation and function by ubiquitin-specific proteases.

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recommendations! Published in 2019 at "Cellular immunology"

DOI: 10.1016/j.cellimm.2019.103922

Abstract: T cells play critical roles in immune responses to pathogens, autoimmunity, and antitumor immunity. During the past few decades, increasing numbers of studies have demonstrated the significance of protein ubiquitination in T cell-mediated immunity. Several… read more here.

Keywords: specific proteases; cell differentiation; ubiquitin specific; differentiation function ... See more keywords
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The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition.

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recommendations! Published in 2017 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2017.12.003

Abstract: Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue of Cell Chemical Biology, Lamberto et al. (2017) and Pozhidaeva et al. (2017) report important insights into the… read more here.

Keywords: step forward; next step; specific protease; ubiquitin specific ... See more keywords

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

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recommendations! Published in 2023 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.2c01933

Abstract: USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquitinating enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been reported as a promising novel therapeutic target for cancer treatment. Herein,… read more here.

Keywords: bay 805; specific protease; inhibitor; ubiquitin specific ... See more keywords

Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c00102

Abstract: Protein ubiquitination is a reversible post-translational modification regulated by ubiquitin-conjugating and deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 7 (USP7), a well-characterized DUB, plays multifaceted roles in various cellular processes, making it a promising therapeutic target. The… read more here.

Keywords: protease usp7; drug discovery; ubiquitin specific; therapeutic target ... See more keywords

Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c03150

Abstract: Ubiquitin-Specific Protease 7 (USP7) has emerged as a critical therapeutic target in cancer due to its regulatory roles of tumor suppressors, oncoproteins, and epigenetic modifiers. In this study, we present a comprehensive drug repurposing strategy… read more here.

Keywords: drug repurposing; protease usp7; physics; ubiquitin specific ... See more keywords
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Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-09497-y

Abstract: Glioblastoma (GBM) patients present poor prognosis. Deubiquitination by deubiquitinating enzymes (DUBs) is a critical process in cancer progression. Ubiquitin-specific proteases (USPs) constitute the largest sub-family of DUBs. Evaluate the role of USP32 in GBM progression… read more here.

Keywords: glioblastoma; protease oncogene; specific protease; oncogene glioblastoma ... See more keywords

Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-88761-3

Abstract: Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ubiquitin from… read more here.

Keywords: spectrum ubiquitin; broad spectrum; ym155; ubiquitin specific ... See more keywords

Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep43180

Abstract: The overexpression of Mdm2 has been linked to the loss of p53 tumour suppressor activity in several human cancers. Here, we present results suggesting that ubiquitin-specific peptidase 48 (USP48), a deubiquitinase that has been linked… read more here.

Keywords: deubiquitinase; specific peptidase; deubiquitinase activity; mdm2 ... See more keywords