The Ubiquitin System: a Regulatory Hub for Intellectual Disability and Autism Spectrum Disorder
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01881-x
Abstract: Intellectual disability (ID) and autism spectrum disorder (ASD) are two of the most common neurodevelopmental disorders. Both disorders are extremely heterogenous, and only ~ 40% of reported cases have so far been attributed to genetic mutations.… read more here.
Keywords: intellectual disability; disability autism; spectrum disorder; ubiquitin system ... See more keywords
Mass spectrometry techniques for studying the ubiquitin system.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20170091
Abstract: Post-translational control of proteins through covalent attachment of ubiquitin plays important roles in all eukaryotic cell functions. The ubiquitin system in humans consists of 2 E1, 35 E2 and >600 E3 ubiquitin ligases as well… read more here.
Keywords: system; mass spectrometry; spectrometry techniques; ubiquitin system ... See more keywords
Targeting the Ubiquitin System in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.574011
Abstract: Glioblastoma is the most common primary brain tumor in adults with poor overall outcome and 5-year survival of less than 5%. Treatment has not changed much in the last decade or so, with surgical resection… read more here.
Keywords: system; glioblastoma; system glioblastoma; targeting ubiquitin ... See more keywords
Ubiquitin System
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19041080
Abstract: Ever since the discovery of ubiquitin in 1975[...]. read more here.
Keywords: ubiquitin system; system;
Role of the Ubiquitin System in Stress Granule Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073624
Abstract: Eukaryotic cells react to various stress conditions with the rapid formation of membrane-less organelles called stress granules (SGs). SGs form by multivalent interactions between RNAs and RNA-binding proteins and are believed to protect stalled translation… read more here.
Keywords: role ubiquitin; ubiquitin system; metabolism; stress ... See more keywords
The Role of the Host Ubiquitin System in Promoting Replication of Emergent Viruses
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13030369
Abstract: Ubiquitination of proteins is a post-translational modification process with many different cellular functions, including protein stability, immune signaling, antiviral functions and virus replication. While ubiquitination of viral proteins can be used by the host as… read more here.
Keywords: replication; ubiquitin system; emergent viruses; host ubiquitin ... See more keywords
Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.73790
Abstract: Ferroptosis is a novel type of regulated cell death driven by the excessive accumulation of iron-dependent lipid peroxidation. Therapy-resistant tumor cells, particularly those in the mesenchymal-like state and prone to metastasis, are highly susceptible to… read more here.
Keywords: strategy cancer; ubiquitin system; ferroptosis; system enzymes ... See more keywords