Detecting Active Deconjugating Enzymes with Genetically Encoded Activity-Based Ubiquitin and Ubiquitin-like Protein Probes.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03270
Abstract: Post-translational modification of proteins by Ubiquitin (Ub) and Ubiquitin-like proteins (Ubls) can be reversed by deconjugating enzymes, which have been implicated in different pathways and associated with various human diseases. To understand the activity and… read more here.
Keywords: ubl probes; ubiquitin like; genetically encoded; activity ... See more keywords
Ubiquitin and Ubiquitin-like proteins in cardiac disease and protection.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug targets"
DOI: 10.2174/1389450117666151209114608
Abstract: Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity.… read more here.
Keywords: like proteins; ubiquitin like; cardiac disease; disease protection ... See more keywords
A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
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DOI: 10.2210/pdb6h3a/pdb
Abstract: Summary Ubiquitylation, the posttranslational linkage of ubiquitin moieties to lysines in target proteins, helps regulate a myriad of biological processes. Ubiquitin, and sometimes ubiquitin-homology domains, are recognized by ubiquitin-binding domains, including CUE domains. CUE domains are… read more here.
Keywords: domain; cue domains; ubiquitin ubiquitin; ubiquitin binding ... See more keywords
Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid
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DOI: 10.3390/molecules26092619
Abstract: Dehydroalanine exists natively in certain proteins and can also be chemically made from the protein cysteine. As a strong Michael acceptor, dehydroalanine in proteins has been explored to undergo reactions with different thiolate reagents for… read more here.
Keywords: protein; thiocyanatobenzoic acid; dehydroalanine; ubiquitin ubiquitin ... See more keywords