Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif
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DOI: 10.1002/pro.3593
Abstract: We previously described structural and functional characterization of the first ubiquitin variant (UbV), UbV.v27.1, engineered by phage display to bind with high affinity to a specific ubiquitin interacting motif (UIM). We identified two substitutions relative… read more here.
Keywords: interacting motif; high affinity; affinity; dimerization ... See more keywords
Targeted Degradation of 53BP1 Using Ubiquitin Variant Induced Proximity
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DOI: 10.3390/biom12040479
Abstract: In recent years, researchers have leveraged the ubiquitin-proteasome system (UPS) to induce selective degradation of proteins by E3 ubiquitin ligases, which has great potential as novel therapeutics for human diseases, including cancer and neurodegenerative disorders.… read more here.
Keywords: ubiquitin variant; targeted degradation; proximity; variant induced ... See more keywords