Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.05.013
Abstract: Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination. read more here.
Keywords: histone h3k79; ubiquitinated nucleosome; methylation histone; histone ... See more keywords
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53199
Abstract: Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by Set1, the methyltransferase subunit of COMPASS. We report here… read more here.
Keywords: compass; ubiquitinated nucleosome; structure; h2b ... See more keywords