G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46237-1
Abstract: The aberrant accumulation of ubiquitinated protein aggregates in cells plays a critical role in the pathogenesis of several degenerative diseases, including Parkinson disease (PD) and cystic fibrosis (CF). In this study, we found that Ras… read more here.
Keywords: aggregation; ubiquitinated protein; g3bp1 inhibits; p62 usp10 ... See more keywords
Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2037852
Abstract: SQSTM1/p62-type selective macroautophagy/autophagy receptors cross-link poly-ubiquitinated cargo and autophagosomal LC3/Atg8 proteins to deliver them for lysosomal degradation. Consequently, loss of autophagy leads to accumulation of polyubiquitinated protein aggregates that are also frequently seen in various… read more here.
Keywords: cnc nfe2l2; protein autophagy; autophagy; nfe2l2 nrf2 ... See more keywords