Total chemical and semisynthetic approaches for the preparation of ubiquitinated proteins and their applications
Sign Up to like & getrecommendations! Published in 2017 at "Science China Chemistry"
DOI: 10.1007/s11426-017-9122-3
Abstract: Protein ubiquitination is an important post-translational modification (PTM) in eukaryotic organisms that regulates a variety of cellular processes, such as protein degradation, signal transduction, apoptosis, and DNA damage tolerance. To decipher mechanistically the diverse biological… read more here.
Keywords: semisynthetic approaches; total chemical; ubiquitinated proteins; chemical semisynthetic ... See more keywords
Impaired autophagy promotes bile acid-induced hepatic injury and accumulation of ubiquitinated proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.202
Abstract: Chronic exposure to hydrophobic bile acids such as chenodeoxycholic acid (CDCA) and cholic acid (CA) in the liver during cholestasis causes hepatotoxicity and inflammatory response. However, the detailed mechanisms regarding the role of autophagy in… read more here.
Keywords: accumulation; bile acids; ubiquitinated proteins; acid induced ... See more keywords
IMPAIRED AUTOPHAGIC FLUX CONTRIBUTES TO THE ACCUMULATION OF UBIQUITINATED PROTEINS IN A MOUSE MODEL OF HEART FAILURE
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)34261-4
Abstract: Background: In the failing heart there is impaired protein turnover and an accumulation of ubiquitinated proteins within cardiomyocytes. This accumulation, which likely has detrimental effects on myocyte function, has been attributed to proteasome dysfunction. However,… read more here.
Keywords: heart; ubiquitinated proteins; accumulation ubiquitinated; autophagic flux ... See more keywords
Proteome-wide identification and functional analysis of ubiquitinated proteins in peach leaves
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59342-3
Abstract: Ubiquitination is a critical post-translational modification machinery that governs a wide range of cellular functions by regulating protein homeostasis. Identification of ubiquitinated proteins and lysine residues can help researchers better understand the physiological roles of… read more here.
Keywords: wide identification; ubiquitinated proteins; analysis; proteome wide ... See more keywords
Nuclear export of ubiquitinated proteins via the UBIN-POST system
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1711017115
Abstract: Significance It is commonly observed that proteasome impairment results in accumulation of ubiquitinated proteins in the cytosol. Even proteins originally located in the nucleus show similar cytosolic accumulation, suggesting that unidentified machinery proactively transports them… read more here.
Keywords: protein; ubin post; ubiquitinated proteins; nuclear export ... See more keywords
Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-212617
Abstract: Objectives To assess if ubiquitinated proteins potentially present in neutrophil extracellular traps (NETs) can modify cellular responses and induce inflammatory mechanisms in patients with systemic lupus erythematosus (SLE) and healthy subjects. Materials and methods We… read more here.
Keywords: ubiquitinated proteins; systemic lupus; lupus erythematosus; ubiquitination nets ... See more keywords
Quantitative Ubiquitinomics Revealed Abnormal Ubiquitinated ATP7A Involved in Down-Regulation of ACTH in Silent Corticotroph Adenomas
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.863017
Abstract: Ubiquitination is reported to be a critical biological event on ACTH secretion in corticotroph adenomas. However, the effect of ubiquitylation on ACTH secretion in silent corticotroph adenomas (SCAs) remains unclear. The aim of our study… read more here.
Keywords: ubiquitinated proteins; corticotroph adenomas; secretion; silent corticotroph ... See more keywords
Comparative Ubiquitination Proteomics Revealed the Salt Tolerance Mechanism in Sugar Beet Monomeric Additional Line M14
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416088
Abstract: Post-translational modifications (PTMs) are important molecular processes that regulate organismal responses to different stresses. Ubiquitination modification is not only involved in human health but also plays crucial roles in plant growth, development, and responses to… read more here.
Keywords: ubiquitinated proteins; sugar beet; additional line; monomeric additional ... See more keywords