Programmed ubiquitin acetylation using genetic code expansion reveals altered ubiquitination patterns
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13702
Abstract: Ubiquitination is a post‐translational modification (PTM) capable of being regulated by other PTMs, including acetylation. However, the biological consequences of acetylated ubiquitin (acUb) variants are poorly understood, due to their transient nature in vivo and… read more here.
Keywords: code expansion; acetylation; ubiquitination patterns; using genetic ... See more keywords
Linear ubiquitination‐induced necrotic tumor remodeling elicits immune evasion
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14623
Abstract: Tumor‐elicited inflammation confers tumorigenic properties, including cell death resistance, proliferation, or immune evasion. To focus on inflammatory signaling in tumors, we investigated linear ubiquitination, which enhances the nuclear factor‐κB signaling pathway and prevents extrinsic programmed… read more here.
Keywords: immune evasion; ubiquitination induced; linear ubiquitination; tumor ... See more keywords
Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202000871
Abstract: Abstract The Legionella pneumophila effector MavC is a transglutaminase that carries out atypical ubiquitination of the host ubiquitin (Ub)‐conjugation enzyme UBE2N by catalyzing the formation of an isopeptide bond between Gln40Ub and Lys92UBE2N, which leads… read more here.
Keywords: mavc; transglutaminase; molecular basis; basis ubiquitination ... See more keywords
TRAF4‐Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation‐Induced Colorectal Cancer Progression
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202301164
Abstract: Mechanistic target of rapamycin complex 1 (mTORC1) is a conserved serine/threonine kinase that integrates various environmental signals to regulate cell growth and metabolism. mTORC1 activation requires tethering to lysosomes by the Ragulator‐Rag complex. However, the… read more here.
Keywords: inflammation induced; ubiquitination; mtorc1 activation; activation ... See more keywords
A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202409173
Abstract: Intrahepatic cholangiocarcinoma (ICC), a formidable challenge in oncology, demands innovative biomarkers and therapeutic targets. This research highlights the importance of the circular RNA (circRNA) circPCSK6 and its peptide derivative circPCSK6‐167aa in ICC. CircPCSK6 is significantly… read more here.
Keywords: circpcsk6; ubiquitination; intrahepatic cholangiocarcinoma; circpcsk6 167aa ... See more keywords
The role and advance of ubiquitination and deubiquitination in depression pathogenesis and treatment
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.70005
Abstract: Depression is a common neuropsychiatric disease that is characterized by long‐term, repeated low mood, pain and despair, pessimism, and even suicidal tendencies. Increasing evidence has shown that ubiquitination and deubiquitination are closely related to the… read more here.
Keywords: ubiquitination deubiquitination; ubiquitination; treatment; depression ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
Aloe emodin relieves Ang II‐induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0520-582r
Abstract: Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease,… read more here.
Keywords: activation; microscopy; ubiquitination; nlrp3 inflammasome ... See more keywords
K27‐linked noncanonic ubiquitination in immune regulation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ru0620-397rr
Abstract: Ubiquitination is a common form of posttranslational modification that has been implicated in regulating considerable immune signaling pathways. The functions of canonic K48‐ and K63‐linked ubiquitination have been well studied. However, the roles of noncanonic… read more here.
Keywords: noncanonic ubiquitination; k27 linked; linked ubiquitination; linked noncanonic ... See more keywords
Emerging Roles and Research Tools of Atypical Ubiquitination
Sign Up to like & getrecommendations! Published in 2020 at "PROTEOMICS"
DOI: 10.1002/pmic.201900100
Abstract: Ubiquitination is a posttranslational modification characterized by the covalent attachment of ubiquitin molecules to protein substrates. The ubiquitination modification process is reversible, dynamic, and involved in the regulation of various biological processes, such as autophagy,… read more here.
Keywords: roles research; research; emerging roles; tools atypical ... See more keywords
Systematic analysis of the ubiquitome in mouse testis
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202100025
Abstract: A growing body of evidence now supports the fact that protein ubiquitination is an important modification during the regulation of spermatogenesis. However, little is known about the ubiquitome of the testis. In this study, we… read more here.
Keywords: testis; mouse testis; systematic analysis; ubiquitome mouse ... See more keywords