Programmed ubiquitin acetylation using genetic code expansion reveals altered ubiquitination patterns
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13702
Abstract: Ubiquitination is a post‐translational modification (PTM) capable of being regulated by other PTMs, including acetylation. However, the biological consequences of acetylated ubiquitin (acUb) variants are poorly understood, due to their transient nature in vivo and… read more here.
Keywords: code expansion; acetylation; ubiquitination patterns; using genetic ... See more keywords
Linear ubiquitination‐induced necrotic tumor remodeling elicits immune evasion
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14623
Abstract: Tumor‐elicited inflammation confers tumorigenic properties, including cell death resistance, proliferation, or immune evasion. To focus on inflammatory signaling in tumors, we investigated linear ubiquitination, which enhances the nuclear factor‐κB signaling pathway and prevents extrinsic programmed… read more here.
Keywords: immune evasion; ubiquitination induced; linear ubiquitination; tumor ... See more keywords
Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202000871
Abstract: Abstract The Legionella pneumophila effector MavC is a transglutaminase that carries out atypical ubiquitination of the host ubiquitin (Ub)‐conjugation enzyme UBE2N by catalyzing the formation of an isopeptide bond between Gln40Ub and Lys92UBE2N, which leads… read more here.
Keywords: mavc; transglutaminase; molecular basis; basis ubiquitination ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
Aloe emodin relieves Ang II‐induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0520-582r
Abstract: Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease,… read more here.
Keywords: activation; microscopy; ubiquitination; nlrp3 inflammasome ... See more keywords
K27‐linked noncanonic ubiquitination in immune regulation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ru0620-397rr
Abstract: Ubiquitination is a common form of posttranslational modification that has been implicated in regulating considerable immune signaling pathways. The functions of canonic K48‐ and K63‐linked ubiquitination have been well studied. However, the roles of noncanonic… read more here.
Keywords: noncanonic ubiquitination; k27 linked; linked ubiquitination; linked noncanonic ... See more keywords
Emerging Roles and Research Tools of Atypical Ubiquitination
Sign Up to like & getrecommendations! Published in 2020 at "PROTEOMICS"
DOI: 10.1002/pmic.201900100
Abstract: Ubiquitination is a posttranslational modification characterized by the covalent attachment of ubiquitin molecules to protein substrates. The ubiquitination modification process is reversible, dynamic, and involved in the regulation of various biological processes, such as autophagy,… read more here.
Keywords: roles research; research; emerging roles; tools atypical ... See more keywords
Systematic analysis of the ubiquitome in mouse testis
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202100025
Abstract: A growing body of evidence now supports the fact that protein ubiquitination is an important modification during the regulation of spermatogenesis. However, little is known about the ubiquitome of the testis. In this study, we… read more here.
Keywords: testis; mouse testis; systematic analysis; ubiquitome mouse ... See more keywords
Unique auto‐ubiquitination activities of artificial RING fingers in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3452
Abstract: Ubiquitin‐conjugating (E2) enzymes in protein ubiquitination are associated with various diseases. An artificial RING finger (ARF) is a useful tool, and E2 activities are conveniently estimated based on ARF reactivities. To extend the use of… read more here.
Keywords: auto ubiquitination; artificial ring; tat arf; cancer cells ... See more keywords
Global Mass Spectrometry-Based Analysis of Protein Ubiquitination Using K-ε-GG Remnant Antibody Enrichment.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1665-9_11
Abstract: Ubiquitination is a post-translational modification that affects protein degradation as well as a variety of cellular processes. Methods that globally profile ubiquitination are powerful tools to better understand these processes. Here we describe an updated… read more here.
Keywords: enrichment; antibody; ubiquitination; mass spectrometry ... See more keywords
In Vitro Assay to Study Histone Ubiquitination During Transcriptional Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6518-2_17
Abstract: In mammals, gene expression is largely controlled at the transcriptional level. In response to environmental or intrinsic signaling, gene expression is often fine-tuned by epigenetic modifications, including DNA methylation and histone modifications. One such histone… read more here.
Keywords: histone ubiquitination; vitro assay; assay study; histone ... See more keywords