Snail promotes prostate cancer migration by facilitating SPOP ubiquitination and degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.187
Abstract: Prostate cancer (PCa) is the second leading cause of cancer-associated mortality in men. Speckle-type pox virus and zinc finger protein (SPOP), the most frequently mutated gene in PCa, functions as a tumor suppressor via degradation… read more here.
Keywords: degradation; spop ubiquitination; prostate cancer; snail ... See more keywords
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00843
Abstract: Protein post-translational modification by ubiquitin-fold modifier 1, UFM1, regulates many biological processes such as response to endoplasmic reticulum stress and regulation of tumor progression. A recent study has indicated that the UFM1-binding and PCI domain-containing… read more here.
Keywords: degradation; mechanism; protein ubiquitination; interacting proteins ... See more keywords
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24467
Abstract: Interferon-inducible guanylate-binding proteins (GBPs) mediate cell-autonomous antimicrobial defences. Shigella flexneri, a Gram-negative cytoplasmic free-living bacterium that causes bacillary dysentery, encodes a repertoire of highly similar type III secretion system effectors called invasion plasmid antigen Hs… read more here.
Keywords: degradation; gbps; defence; ipah9 ... See more keywords
GFPT1 promotes the proliferation of cervical cancer via regulating the ubiquitination and degradation of PTEN.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac073
Abstract: Cervical cancer demonstrates the fourth incidence and death rate in female worldwide. Glutamine--fructose-6-phosphate transaminase 1 (GFPT1), the first rate-limited enzyme of hexosamine biosynthesis pathway, has been reported to promote the progression of cancers. However, the… read more here.
Keywords: cervical cancer; proliferation cervical; ubiquitination degradation; gfpt1 ... See more keywords
Let‐7b‐5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15678
Abstract: Naked cuticle homolog 1 (NKD1), which is expressed at low levels in many tumors, is considered an inhibitor of the Wnt/β‐catenin pathway, but it is highly expressed in colon cancer and can promote colon cancer… read more here.
Keywords: progression; ubiquitination degradation; targeting nkd1; colon cancer ... See more keywords
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0183774
Abstract: Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas binding of vasopressin to its type-2 receptor initiates a cAMP-protein… read more here.
Keywords: ubiquitination degradation; degradation; nedd4 nedd4l; aqp2 ubiquitination ... See more keywords
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Reports"
DOI: 10.15252/embr.202152576
Abstract: The E3 ubiquitin ligase complex CDC20‐activated anaphase‐promoting complex/Cyclosome (APC/CCDC20) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division cycle protein 20 homolog (CDC20), the co‐activator of… read more here.
Keywords: bone formation; cdc20; ubiquitination degradation; p65 ... See more keywords
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine Connections"
DOI: 10.1530/ec-22-0459
Abstract: Background Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS. However,… read more here.
Keywords: cell; gpx4 ubiquitination; cell ferroptosis; ubiquitination degradation ... See more keywords
Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0502
Abstract: ARMC5 (Armadillo repeat containing 5) was identified as a new tumor suppressor gene responsible for hereditary adrenocortical tumors and meningiomas. ARMC5 is ubiquitously expressed and encodes a protein which contains a N-terminal Armadillo repeat domain… read more here.
Keywords: tumor suppressor; suppressor gene; armc5 ubiquitination; ubiquitination degradation ... See more keywords
Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s238695
Abstract: Background Ubiquitin-fold modifier-1 (Ufm1) is a recently identified ubiquitin-like protein. We previously confirmed that Ufm1 expression was increased in diabetic mice. However, its role in the development of diabetes remains undefined. Methods Lentivirus-mediated gene knockdown… read more here.
Keywords: p65 nuclear; ubiquitin fold; ubiquitination degradation; nuclear translocation ... See more keywords