Snail promotes prostate cancer migration by facilitating SPOP ubiquitination and degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.187
Abstract: Prostate cancer (PCa) is the second leading cause of cancer-associated mortality in men. Speckle-type pox virus and zinc finger protein (SPOP), the most frequently mutated gene in PCa, functions as a tumor suppressor via degradation… read more here.
Keywords: degradation; spop ubiquitination; prostate cancer; snail ... See more keywords
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00843
Abstract: Protein post-translational modification by ubiquitin-fold modifier 1, UFM1, regulates many biological processes such as response to endoplasmic reticulum stress and regulation of tumor progression. A recent study has indicated that the UFM1-binding and PCI domain-containing… read more here.
Keywords: degradation; mechanism; protein ubiquitination; interacting proteins ... See more keywords
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24467
Abstract: Interferon-inducible guanylate-binding proteins (GBPs) mediate cell-autonomous antimicrobial defences. Shigella flexneri, a Gram-negative cytoplasmic free-living bacterium that causes bacillary dysentery, encodes a repertoire of highly similar type III secretion system effectors called invasion plasmid antigen Hs… read more here.
Keywords: degradation; gbps; defence; ipah9 ... See more keywords
GFPT1 promotes the proliferation of cervical cancer via regulating the ubiquitination and degradation of PTEN.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac073
Abstract: Cervical cancer demonstrates the fourth incidence and death rate in female worldwide. Glutamine--fructose-6-phosphate transaminase 1 (GFPT1), the first rate-limited enzyme of hexosamine biosynthesis pathway, has been reported to promote the progression of cancers. However, the… read more here.
Keywords: cervical cancer; proliferation cervical; ubiquitination degradation; gfpt1 ... See more keywords
Let‐7b‐5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15678
Abstract: Naked cuticle homolog 1 (NKD1), which is expressed at low levels in many tumors, is considered an inhibitor of the Wnt/β‐catenin pathway, but it is highly expressed in colon cancer and can promote colon cancer… read more here.
Keywords: progression; ubiquitination degradation; targeting nkd1; colon cancer ... See more keywords
The ubiquitination degradation of KLF15 mediated by WSB2 promotes lipogenesis and progression of hepatocellular carcinoma via inhibiting PDLIM2 expression
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16812
Abstract: Krüppel‐like factors15 (KLF15) is a cancer suppressor in many cancers. However, its precise function in the development of hepatocellular carcinoma (HCC) remains unclear. Lipogenesis is necessary for the development of HCC. This research aims to… read more here.
Keywords: ubiquitination degradation; progression; degradation klf15; klf15 ... See more keywords
ARRDC1 inhibits the replication of Semliki Forest virus by regulating the ubiquitination and degradation of viral nsP4
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.00977-25
Abstract: ABSTRACT Alphavirus infection can result in a spectrum of clinical manifestations in the host, including fever, rash, arthritis, and even symptoms of encephalitis, thereby posing a severe threat to global public health security. In this… read more here.
Keywords: replication; ubiquitination degradation; forest virus; arrdc1 ... See more keywords
N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Cell International"
DOI: 10.1186/s12935-024-03551-7
Abstract: Increasing evidence supports the crucial role of Epithelial-Mesenchymal Transition (EMT) in cancer invasion and metastasis. N-acetylglucosaminyltransferase V (MGAT5), which is associated with multiantenna glycosylation, can contribute to tumorigenesis, yet its specific role in promoting colorectal… read more here.
Keywords: colorectal cancer; cancer; ubiquitination degradation; acetylglucosaminyltransferase ... See more keywords
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0183774
Abstract: Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas binding of vasopressin to its type-2 receptor initiates a cAMP-protein… read more here.
Keywords: ubiquitination degradation; degradation; nedd4 nedd4l; aqp2 ubiquitination ... See more keywords
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Reports"
DOI: 10.15252/embr.202152576
Abstract: The E3 ubiquitin ligase complex CDC20‐activated anaphase‐promoting complex/Cyclosome (APC/CCDC20) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division cycle protein 20 homolog (CDC20), the co‐activator of… read more here.
Keywords: bone formation; cdc20; ubiquitination degradation; p65 ... See more keywords
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine Connections"
DOI: 10.1530/ec-22-0459
Abstract: Background Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS. However,… read more here.
Keywords: cell; gpx4 ubiquitination; cell ferroptosis; ubiquitination degradation ... See more keywords