Mdm2-mediated ubiquitination of PKCĪ²II in the nucleus mediates clathrin-mediated endocytic activity.
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DOI: 10.1016/j.bcp.2019.113675
Abstract: Cellular stimuli that increase diacylglycerol levels activate several protein kinase C (PKC) isoforms; however, prolonged stimulation depletes cells of PKCs. Ubiquitination is a critical cellular event that mediates the degradation of numerous proteins, including PKCs,… read more here.
Keywords: nucleus; clathrin mediated; mdm2; ubiquitination pkc ... See more keywords