iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109642
Abstract: Post-translational modification of ribosomal proteins enables rapid and dynamic regulation of protein biogenesis. Site-specific ubiquitylation of 40S ribosomal proteins uS10 and eS10 plays a key role during ribosome-associated quality control (RQC). Distinct, and previously functionally… read more here.
Keywords: 40s ribosomal; initiation; ubiquitylation; translation ... See more keywords
TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2022.105673
Abstract: BACKGROUND Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with… read more here.
Keywords: scfcyclin complex; ubiquitylation; tdp; als ftd ... See more keywords
Ubiquitylation at the crossroads of development and disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.83
Abstract: Human development requires intricate cell specification and communication pathways that allow an embryo to generate and appropriately connect more than 200 different cell types. Key to the successful completion of this differentiation programme is the… read more here.
Keywords: development disease; ubiquitylation crossroads; ubiquitylation; crossroads development ... See more keywords
Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03566-4
Abstract: Ubiquitylation is a widespread post-translational protein modification in eukaryotes and marks bacteria that invade the cytosol as cargo for antibacterial autophagy1-3. The identity of the ubiquitylated substrate on bacteria is unknown. Here we show that… read more here.
Keywords: ubiquitylation lipopolysaccharide; invade cytosol; lipopolysaccharide rnf213; ubiquitylation ... See more keywords
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0227-4
Abstract: Post-translational modification of proteins with ubiquitin and ubiquitin-like proteins (Ubls) is central to the regulation of eukaryotic cellular processes. Our ability to study the effects of ubiquitylation, however, is limited by the difficulty to prepare… read more here.
Keywords: code expansion; site specific; ubiquitylation; sortase ... See more keywords
Non-proteolytic ubiquitylation in cellular signaling and human disease
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03060-1
Abstract: Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such… read more here.
Keywords: cellular signaling; ubiquitylation; non proteolytic; disease ... See more keywords
Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Journal"
DOI: 10.1042/bcj20161104
Abstract: Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP… read more here.
Keywords: ubiquitylation; ubiquitin chains; domain; rnf52 domain ... See more keywords
Analysis of defective protein ubiquitylation associated to adriamycin resistant cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1387694
Abstract: ABSTRACT DNA damage activated by Adriamycin (ADR) promotes ubiquitin–proteasome system-mediated proteolysis by stimulating both the activity of ubiquitylating enzymes and the proteasome. In ADR-resistant breast cancer MCF7 (MCF7ADR) cells, protein ubiquitylation is significantly reduced compared… read more here.
Keywords: analysis defective; mcf7adr cells; ubiquitylation; protein ubiquitylation ... See more keywords
Abstract A038: Establishing ubiquitylation pattern in tissues and cells efficient method to monitor cancer drug function and biomarkers
Sign Up to like & getrecommendations! Published in 2018 at "Biomarkers"
DOI: 10.1158/1535-7163.targ-17-a038
Abstract: The cell regulates its function by altering ubiquitylation status of many key proteins, especially oncoproteins. As a result, these ubiquitin proteasome system (UPS) substrates and the relevant UPS enzymes have been identified as attractive anticancer… read more here.
Keywords: ubiquitylation; establishing ubiquitylation; drug; ubiquitylation pattern ... See more keywords
An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006438
Abstract: Apoptosis is an evolutionary conserved cell death mechanism, which requires activation of initiator and effector caspases. The Drosophila initiator caspase Dronc, the ortholog of mammalian Caspase-2 and Caspase-9, has an N-terminal CARD domain that recruits… read more here.
Keywords: caspase; non apoptotic; ubiquitylation; dronc ... See more keywords
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000768
Abstract: A new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy. The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria.… read more here.
Keywords: mitochondrial ubiquitylation; usp30 sets; ubiquitylation; amplification mitochondrial ... See more keywords