Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer’s disease
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DOI: 10.1016/j.neuroimage.2021.118248
Abstract: Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer’s disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is… read more here.
Keywords: volume; alzheimer disease; ucb pet; correction ... See more keywords
Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour
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DOI: 10.1186/s13550-020-00721-2
Abstract: Background Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([ 11 C]UCB-J) provides the opportunity to visualize synaptic density changes in vivo,… read more here.
Keywords: pet; ucb pet; model; autoradiography ... See more keywords
Validation and test–retest repeatability performance of parametric methods for [11C]UCB-J PET
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DOI: 10.1186/s13550-021-00874-8
Abstract: [ 11 C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [ 11 C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this… read more here.
Keywords: reference; retest repeatability; parametric methods; ucb pet ... See more keywords