Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.10.019
Abstract: Background The pharmacological activation of thermogenesis in brown adipose tissue has long been considered promising strategies to treat obesity. However, identification of safe and effective agents remains a challenge. In this study, we addressed this… read more here.
Keywords: ucp1 expression; approved drugs; obesity; fda approved ... See more keywords
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04019-8
Abstract: Adipocytes increase energy expenditure in response to prolonged sympathetic activation via persistent expression of uncoupling protein 1 (UCP1)1,2. Here we report that the regulation of glycogen metabolism by catecholamines is critical for UCP1 expression. Chronic β-adrenergic… read more here.
Keywords: metabolism; ucp1 expression; glycogen metabolism; glycogen ... See more keywords
Cinnamon induces browning in subcutaneous adipocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02263-5
Abstract: Browning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive… read more here.
Keywords: ucp1 expression; adipose tissue; browning effect; adipocytes markers ... See more keywords
Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice
Sign Up to like & getrecommendations! Published in 2020 at "Nutrients"
DOI: 10.3390/nu12051459
Abstract: Sesamol found in sesame oil has been shown to ameliorate obesity by regulating lipid metabolism. However, its effects on energy expenditure and the underlying molecular mechanism have not been clearly elucidated. In this study, we… read more here.
Keywords: energy expenditure; ucp1 expression; sesamol; energy ... See more keywords
Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.31951
Abstract: Identification of proper agents to increase or activate UCP1+ cells in adipose tissues remains a potent therapeutic strategy to combat obesity. Screening systems for UCP1 activators have been previously established and allow for unbiased discovery… read more here.
Keywords: identification rhodanine; ucp1 expression; bml 260;