UCP2 regulates cholangiocarcinoma cell plasticity via mitochondria-to-AMPK signals.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.017
Abstract: Uncoupling protein 2 (UCP2) is upregulated in several human cancers which contributes to tumorigenesis. However, whether UCP2 expression is amplified in cholangiocarcinoma and whether UCP2 promotes cholangiocarcinoma progression are not known. Our results found that… read more here.
Keywords: ucp2 expression; cholangiocarcinoma cells; ucp2 regulates; cholangiocarcinoma ... See more keywords
Response of skeletal muscle UCP2-expression during metabolic adaptation to caloric restriction
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DOI: 10.1038/s41366-018-0085-2
Abstract: Background/objectivesSpendthrift vs. thrifty individuals expend more energy and experience greater weight loss during caloric restriction (CR). Adaptive mechanisms in skeletal muscle, adipose tissue, and on hormone level modulate energy expenditure (EE) during weight loss. Metabolic… read more here.
Keywords: skeletal muscle; ucp2 expression; muscle; weight loss ... See more keywords
Uncoupling Protein 2 in Cardiovascular Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01060
Abstract: Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. It uncouples oxygen consumption from ATP synthesis. UCP2 is ubiquitously expressed in most cell types to reduce oxidative stress. It is tightly… read more here.
Keywords: ucp2 expression; dysfunction; stress; uncoupling protein ... See more keywords