Articles with "udp acetylglucosamine" as a keyword



Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.

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Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c00888

Abstract: This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas aeruginosa LpxA with no… read more here.

Keywords: acetylglucosamine acyltransferase; chemistry; acyltransferase lpxa; udp acetylglucosamine ... See more keywords

An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP-N-acetylglucosamine transferase

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Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.1008078

Abstract: The second step of eukaryotic lipid-linked oligosaccharide (LLO) biosynthesis is catalyzed by the conserved ALG13/ALG14 heterodimeric UDP-N-acetylglucosamine transferase (GnTase). In humans, mutations in ALG13 or ALG14 lead to severe neurological disorders with a multisystem phenotype,… read more here.

Keywords: human alg13; heterodimeric udp; udp acetylglucosamine; acetylglucosamine transferase ... See more keywords
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UDP-N-Acetylglucosamine Pyrophosphorylase 2 (UAP2) and 1 (UAP1) Perform Synergetic Functions for Leaf Survival in Rice

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Published in 2021 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2021.685102

Abstract: Functional inactivation of UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) induces defense response-related lesion-mimic spots and subsequent early senescence in every newly grown leaf of the rice mutant uap1 after a short period's normal growth. However, the molecular… read more here.

Keywords: rice; udp acetylglucosamine; uap2 uap1; gene ... See more keywords
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Molecular Characterization of UDP-N-Acetylglucosamine Pyrophosphorylase and Its Role in the Growth and Development of the White-Backed Planthopper Sogatella furcifera (Hemiptera: Delphacidae)

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Published in 2022 at "Genes"

DOI: 10.3390/genes13081340

Abstract: UDP-N-acetylglucosamine pyrophosphorylase (UAP) is a key enzyme in the chitin biosynthesis pathway of insects. Here, we described the gene SfUAP in the white-backed planthopper Sogatella furcifera (Horváth) with an open reading frame of 1470 bp.… read more here.

Keywords: backed planthopper; furcifera; acetylglucosamine pyrophosphorylase; planthopper sogatella ... See more keywords