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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00888
Abstract: This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas aeruginosa LpxA with no…
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Keywords:
acetylglucosamine acyltransferase;
chemistry;
acyltransferase lpxa;
udp acetylglucosamine ... See more keywords
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Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1008078
Abstract: The second step of eukaryotic lipid-linked oligosaccharide (LLO) biosynthesis is catalyzed by the conserved ALG13/ALG14 heterodimeric UDP-N-acetylglucosamine transferase (GnTase). In humans, mutations in ALG13 or ALG14 lead to severe neurological disorders with a multisystem phenotype,…
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Keywords:
human alg13;
heterodimeric udp;
udp acetylglucosamine;
acetylglucosamine transferase ... See more keywords
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Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.685102
Abstract: Functional inactivation of UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) induces defense response-related lesion-mimic spots and subsequent early senescence in every newly grown leaf of the rice mutant uap1 after a short period's normal growth. However, the molecular…
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Keywords:
rice;
udp acetylglucosamine;
uap2 uap1;
gene ... See more keywords
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Published in 2022 at "Genes"
DOI: 10.3390/genes13081340
Abstract: UDP-N-acetylglucosamine pyrophosphorylase (UAP) is a key enzyme in the chitin biosynthesis pathway of insects. Here, we described the gene SfUAP in the white-backed planthopper Sogatella furcifera (Horváth) with an open reading frame of 1470 bp.…
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Keywords:
backed planthopper;
furcifera;
acetylglucosamine pyrophosphorylase;
planthopper sogatella ... See more keywords