Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
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DOI: 10.1038/s41467-021-23745-1
Abstract: The antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci develop resistance to 5-FC at… read more here.
Keywords: glucuronic acid; udp glucuronic; resistance; high frequency ... See more keywords