1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecular NMR assignments"
DOI: 10.1007/s12104-021-10024-9
Abstract: The human UDP-glucuronosyltransferase (UGT) family of enzymes catalyze the covalent addition of glucuronic acid to a wide range of compounds, generally rendering them inactive. Although important for clearance of environmental toxins and metabolites, UGT activation… read more here.
Keywords: 13c 15n; human udp; terminal domain; udp glucuronosyltransferase ... See more keywords
Functional and molecular characterization of UDP‐glucuronosyltransferase 2 family in cynomolgus macaques
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.03.002
Abstract: Graphical abstract Figure. No caption available. &NA; UDP‐glucuronosyltransferases (UGTs) are essential enzymes metabolizing endogenous and exogenous chemicals. However, characteristics of UGTs have not been fully investigated in molecular levels of cynomolgus macaques, one of non‐human… read more here.
Keywords: molecular characterization; functional molecular; udp glucuronosyltransferase; cynomolgus macaques ... See more keywords
Insight into Tartrate Inhibition Patterns in vitro and in vivo Based on Cocrystal Structure with UDP-glucuronosyltransferase 2B15.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113753
Abstract: Glucuronidation, catalyzed by UDP-glucuronosyltransferases (UGTs), is a crucial substance metabolism and elimination process that mostly occurs in the liver to protect the body from toxic substances and maintain homeostasis. The reaction functions well in a… read more here.
Keywords: cocrystal structure; udp glucuronosyltransferase; tartrate; based cocrystal ... See more keywords
In vitro metabolism of auriculasin and its inhibitory effects on human cytochrome P450 and UDP-glucuronosyltransferase enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00307
Abstract: Auriculasin has a wide range of pharmacological effects, including anticancer and anti-inflammatory effects. In this work, we explored the metabolic characteristics and inhibitory effect of auriculasin against cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in… read more here.
Keywords: metabolism; metabolism auriculasin; cytochrome p450; udp glucuronosyltransferase ... See more keywords
Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5
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DOI: 10.1124/dmd.118.084947
Abstract: Accumulating evidence indicates that several human UDP-glucuronosyltransferase (UGT) enzymes catalyze both glucuronidation and glucosidation reactions. Baculovirus-infected insect cells [Trichoplusia ni and Spodoptera frugiperda (Sf9)] are used widely for the expression of recombinant human UGT enzymes.… read more here.
Keywords: udp glucuronosyltransferase; glucosidation; glucuronidation; control ... See more keywords
Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
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DOI: 10.1124/dmd.121.000644
Abstract: The human UDP-glucuronosyltransferases (UGTs) represent an important family of drug-metabolizing enzymes, with UGT1A1 targeting the conjugation and detoxification of many exogenous substances, including pharmaceutical drugs. In this study we generated humanized UGT1A1 mice expressing the… read more here.
Keywords: udp glucuronosyltransferase; tissue; glucuronosyltransferase 1a1; tissue specific ... See more keywords
Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver
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DOI: 10.1124/dmd.122.001041
Abstract: Dimethandrolone undecanoate (DMAU), an oral investigational male hormonal contraceptive, is a prodrug that is rapidly converted to its active metabolite, dimethandrolone (DMA). Poor and variable oral bioavailability of DMA after DMAU dosing is a critical… read more here.
Keywords: liver; dma; udp glucuronosyltransferase; dimethandrolone ... See more keywords
Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences
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DOI: 10.3390/ijms24021454
Abstract: Gypensapogenin C (GPC) is one of the important aglycones of Gynostemma pentaphyllum (GP), which is structurally glucuronidated and is highly likely to bind to UGT enzymes in vivo. Due to the important role of glucuronidation… read more here.
Keywords: human udp; glucuronidation; udp glucuronosyltransferase; gpc ... See more keywords
Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes
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DOI: 10.3390/pharmaceutics11070355
Abstract: Catalposide, an active component of Veronica species such as Catalpa ovata and Pseudolysimachion lingifolium, exhibits anti-inflammatory, antinociceptic, anti-oxidant, hepatoprotective, and cytostatic activities. We characterized the in vitro metabolic pathways of catalposide to predict its pharmacokinetics.… read more here.
Keywords: udp glucuronosyltransferase; catalposide; carboxylesterase; sulfotransferase ... See more keywords