Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target.
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DOI: 10.1073/pnas.2215732120
Abstract: Immunotherapy of PD-L1/PD-1 blockage elicited impressive clinical benefits for cancer treatment. However, the relative low response and therapy resistance highlight the need to better understand the molecular regulation of PD-L1 in tumors. Here, we report that… read more here.
Keywords: dysregulation ufmylation; therapeutic target; ufmylation imparts; ufmylation ... See more keywords